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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1990-5-21
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pubmed:abstractText |
Retinoic acid (RA) induces terminal granulocytic differentiation of the HL-60 promyelocytic leukemia cell line as well as certain other human myeloid leukemias. Specific RA receptors that are members of the steroid-thyroid hormone superfamily of nuclear transcription factors have recently been identified. We developed an HL-60 subclone that was relatively resistant to RA-induced differentiation. Specific nuclear RA receptors in this RA-resistant subclone had a decreased affinity for RA and exhibited a lower molecular weight compared with nuclear RA receptors from the RA-sensitive parental HL-60 cells. Retroviral vector-mediated transduction of a single copy of the RA receptor (RAR-alpha) into this RA-resistant HL-60 subclone restored the sensitivity of these cells to RA. These observations indicate that RAR-alpha plays a critical and central role in mediating RA-induced terminal differentiation of HL-60 leukemia cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-214238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2456573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2538684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2542014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2546152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2546626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2548190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2554072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2631796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-276884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2825025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2825036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2825037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2833708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2836738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2838445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2848318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2901419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-2906112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3167974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3167984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3172344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3283939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3293438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3349904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3520340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3600758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3670297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3785217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-3903518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-427803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-4652000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-4768939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6096220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6276439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6285209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6308652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6893015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6930676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6939451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6955596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-6989400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-7030475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-763363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1970118-944375
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2154-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1970118-Antigens, CD18,
pubmed-meshheading:1970118-Carrier Proteins,
pubmed-meshheading:1970118-Cell Differentiation,
pubmed-meshheading:1970118-Cell Division,
pubmed-meshheading:1970118-Gene Expression Regulation,
pubmed-meshheading:1970118-Granulocytes,
pubmed-meshheading:1970118-Humans,
pubmed-meshheading:1970118-Mutation,
pubmed-meshheading:1970118-Proto-Oncogene Proteins,
pubmed-meshheading:1970118-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:1970118-Receptors, Leukocyte-Adhesion,
pubmed-meshheading:1970118-Receptors, Retinoic Acid,
pubmed-meshheading:1970118-Transfection,
pubmed-meshheading:1970118-Tretinoin,
pubmed-meshheading:1970118-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).
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pubmed:affiliation |
Molecular Medicine Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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