Source:http://linkedlifedata.com/resource/pubmed/id/19700662
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
2009-11-6
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| pubmed:databankReference | |
| pubmed:abstractText |
Viral infection or reactivation remains a major cause of morbidity and mortality after allogeneic stem cell transplantation. We now show that infusions of single cytotoxic T lymphocyte (CTL) lines (5 x 10(6)-1.35 x 10(8) cells/m(2)) with specificity for 2 commonly detected viruses, Epstein-Barr virus (EBV) and adenovirus, can be safely administered to pediatric transplantation recipients receiving partially human leukocyte antigen-matched and haploidentical stem cell grafts (n = 13), without inducing graft-versus-host disease. The EBV-specific component of the CTLs expanded in vivo and persisted for more than 12 weeks, but the adenovirus-specific component only expanded in vivo in the presence of concomitant adenoviral infection. Nevertheless, adenovirus-specific T cells could be detected for at least 8 weeks in peripheral blood, even in CTL recipients without viral infection, provided the adenovirus-specific component of their circulating lymphocytes was first expanded by exposure to adenoviral antigens ex vivo. After infusion, none of these 13 high-risk recipients developed EBV-associated lymphoproliferative disease, while 2 of the subjects had resolution of their adenoviral disease. Hence, bispecific CTLs containing both EBV- and adenovirus-specific T cells can safely reconstitute an antigen responsive "memory" population of CTLs after human leukocyte antigen-mismatched stem cell transplantation and may provide antiviral activity. This trial was registered at www.clinicaltrials.gov as #NCT00590083.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1528-0020
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| pubmed:author |
pubmed-author:BollardCatherine MCM,
pubmed-author:BrennerMalcolm KMK,
pubmed-author:ChristinAnneA,
pubmed-author:CruzConrad RCR,
pubmed-author:GálI SIS,
pubmed-author:GeeAdrian PAP,
pubmed-author:HanleyPatrick JPJ,
pubmed-author:HeslopHelen EHE,
pubmed-author:Kennedy-NasserAlana AAA,
pubmed-author:KranceRobert ARA,
pubmed-author:LeenAnn MAM,
pubmed-author:LeungKathryn SKS,
pubmed-author:MyersGary DGD,
pubmed-author:RooneyCliona MCM
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
5
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4283-92
|
| pubmed:dateRevised |
2011-9-5
|
| pubmed:meshHeading |
pubmed-meshheading:19700662-Adenovirus Infections, Human,
pubmed-meshheading:19700662-Adenoviruses, Human,
pubmed-meshheading:19700662-Adolescent,
pubmed-meshheading:19700662-Cell Line,
pubmed-meshheading:19700662-Child,
pubmed-meshheading:19700662-Child, Preschool,
pubmed-meshheading:19700662-DNA, Viral,
pubmed-meshheading:19700662-Epstein-Barr Virus Infections,
pubmed-meshheading:19700662-Female,
pubmed-meshheading:19700662-Herpesvirus 4, Human,
pubmed-meshheading:19700662-Histocompatibility Testing,
pubmed-meshheading:19700662-Humans,
pubmed-meshheading:19700662-Immunologic Memory,
pubmed-meshheading:19700662-Immunotherapy, Adoptive,
pubmed-meshheading:19700662-Infant,
pubmed-meshheading:19700662-Lymphocyte Depletion,
pubmed-meshheading:19700662-Male,
pubmed-meshheading:19700662-Stem Cell Transplantation,
pubmed-meshheading:19700662-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:19700662-Tissue Donors,
pubmed-meshheading:19700662-Transplantation, Homologous
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation.
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| pubmed:affiliation |
Center for Cell and Gene Therapy and Departments of Pediatrics, Immunology, Medicine, and Virology, Baylor College of Medicine, Texas Children's Hospital and the Methodist Hospital, Houston, TX 77030, USA. amleen@txccc.org
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|