Linked Life Data

19697526

Source:http://linkedlifedata.com/resource/pubmed/id/19697526

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-8-24
pubmed:abstractText
There is strong evidence for the importance of genetic factors in the aetiology of anorexia nervosa (AN). Stress factors can be also associated with the clinical manifestation of AN. The hypothalamic-pituitary-adrenal axis plays an important role in stress control. The increased activity of the hypothalamic-pituitary-adrenal axis in AN is caused by corticotropin-releasing hormone hypersecretion. CRH concentration in cerebrospinal fluid is increased in patients with AN. Intracerebral administration of CRH suppresses appetite. CRH receptor type 2 (CRHR 2) is involved in the appetite suppression effects of CRH. Thus CRHR 2 gene can be a candidate gene for AN. Three CRHR 2 splicing isoforms are known: alpha, b and g. In the hypothalamus, the main appetite control centre, only the isoform CRHR 2alpha is expressed, whose mRNA is characterised by one unique exon 1alpha.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-2674
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-18
pubmed:meshHeading
pubmed:articleTitle
[Molecular analysis of the corticotropin-releasing hormone receptor type 2 gene fragment in anorexia nervosa].
pubmed:affiliation
Klinika Endokrynologii i Diabetologii Wieku Rozwojowego, II Katedra Pediatrii Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract