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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-8-21
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pubmed:abstractText |
Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-10333947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-10780952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-11259621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-11469401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-11832370,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-11947963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-12050251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-12136398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-12562868,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-1773700,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19696902-9886766
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Slc2a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/aminoglycoside N1-acetyltransferase
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pubmed:status |
MEDLINE
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pubmed:issn |
1687-5303
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2009
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
715057
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19696902-Acetyltransferases,
pubmed-meshheading:19696902-Adipocytes,
pubmed-meshheading:19696902-Adipose Tissue,
pubmed-meshheading:19696902-Animals,
pubmed-meshheading:19696902-Base Sequence,
pubmed-meshheading:19696902-Caloric Restriction,
pubmed-meshheading:19696902-Cell Size,
pubmed-meshheading:19696902-DNA Primers,
pubmed-meshheading:19696902-Diabetes Mellitus, Type 2,
pubmed-meshheading:19696902-Disease Models, Animal,
pubmed-meshheading:19696902-Glucose,
pubmed-meshheading:19696902-Glucose Transporter Type 4,
pubmed-meshheading:19696902-Lipoprotein Lipase,
pubmed-meshheading:19696902-Male,
pubmed-meshheading:19696902-Obesity,
pubmed-meshheading:19696902-Oxidation-Reduction,
pubmed-meshheading:19696902-RNA, Messenger,
pubmed-meshheading:19696902-Rats,
pubmed-meshheading:19696902-Rats, Mutant Strains,
pubmed-meshheading:19696902-Rats, Zucker,
pubmed-meshheading:19696902-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.
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pubmed:affiliation |
Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. hisayo.morinaga@jt.com
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pubmed:publicationType |
Journal Article
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