Expression of leukemia inhibitory factor (LIF) by a subset of Müller glia cells has recently been implicated in an endogenous survival response to photoreceptor injury in a model of inherited retinal degeneration. To investigate whether such a LIF-controlled survival pathway might be commonly induced upon photoreceptor injury independently of the nature of the toxic stimulus, we analyzed the role of LIF during light-induced retinal degeneration.
Department of Ophthalmology, Laboratory for Retinal Cell Biology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
