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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-8-19
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pubmed:abstractText |
IL-7 is an essential cytokine in T-cell development and homeostasis. It binds to the IL-7R receptor, a complex of the IL-7Ralpha (CD127) and common gamma (CD132) chains. There is significant interest in evaluating the expression of CD127 on human T-cells as it often decreased in medical conditions leading to lymphopenia. Previous reports showed the usefulness of CD127 as a prognostic marker in viral infections such as HIV, CMV, EBV and HCV. A soluble CD127 (sCD127) is released in plasma and may contribute to disease pathogenesis through its control on IL-7 activities. Measuring sCD127 is important to define its role and may complement existing markers used in lymphopenic disease management. We describe a new quantitative assay for the measurement of sCD127 in plasma and report sCD127 concentrations in healthy adults.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e6690
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pubmed:meshHeading |
pubmed-meshheading:19690616-Adult,
pubmed-meshheading:19690616-Antibodies, Monoclonal,
pubmed-meshheading:19690616-Female,
pubmed-meshheading:19690616-Humans,
pubmed-meshheading:19690616-Male,
pubmed-meshheading:19690616-Middle Aged,
pubmed-meshheading:19690616-Receptors, Interleukin-7,
pubmed-meshheading:19690616-Reference Values,
pubmed-meshheading:19690616-Solubility
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pubmed:year |
2009
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pubmed:articleTitle |
Development of a quantitative bead capture assay for soluble IL-7 receptor alpha in human plasma.
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pubmed:affiliation |
National HIV and Retrovirology Laboratories, Public Health Agency of Canada, Ottawa, Canada. sylvie_faucher@phac-aspc.gc.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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