Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-4-23
|
| pubmed:abstractText |
Thirty-seven strains of Escherichia coli isolated from bacteraemia and 40 faecal strains isolated from healthy individuals were O serogrouped and investigated for the production of colicins, haemolysin (Hly), cytotoxic necrotising factor (CNF), lethal activity for mice, the expression of P fimbriae, mannose-resistant (MRHA) and mannose-sensitive (MSHA) haemagglutination, and relative cell surface hydrophobicity. Virulence factors significantly associated with bacteraemic strains were: serogroups O2, O4, O6, O7, O8 and O75 (54% versus 10%, p less than 0.001), production of Hly (32% versus 8%, p less than 0.02) and CNF (38% versus 10%, p less than 0.01), expression of P fimbriae (27% versus 5%, p less than 0.02), MRHA types III, IVa and IVb (51% versus 8%, p less than 0.001), and possession of a moderate cell surface hydrophobic charge (35% versus 13%, p less than 0.05). Virulence factors were strongly associated with strains expressing defined MRHA types. Thus, all strains belonging to MRHA types III and IVa were toxigenic, whereas only 11% of strains belonging to MRHA types IVb, V or VI were toxigenic (p less than 0.001). Virulence factors were concentrated in strains belonging to O serogroups usually found in E. coli that cause extra-intestinal infections, especially in strains of O4 and O6 groups. The most interesting result of this study was that all 12 P-fimbriate strains expressed the MRHA type IVa and 11 of them synthesised CNF.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose,
http://linkedlifedata.com/resource/pubmed/chemical/Shiga Toxin 1,
http://linkedlifedata.com/resource/pubmed/chemical/cytotoxic necrotizing factor type 1,
http://linkedlifedata.com/resource/pubmed/chemical/heat stable toxin (E coli),
http://linkedlifedata.com/resource/pubmed/chemical/heat-labile enterotoxin, E coli
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2615
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-83
|
| pubmed:dateRevised |
2008-8-20
|
| pubmed:meshHeading |
pubmed-meshheading:1968978-Adolescent,
pubmed-meshheading:1968978-Adult,
pubmed-meshheading:1968978-Aged,
pubmed-meshheading:1968978-Bacterial Toxins,
pubmed-meshheading:1968978-Child,
pubmed-meshheading:1968978-Child, Preschool,
pubmed-meshheading:1968978-Cytotoxins,
pubmed-meshheading:1968978-Enterotoxins,
pubmed-meshheading:1968978-Escherichia coli,
pubmed-meshheading:1968978-Escherichia coli Proteins,
pubmed-meshheading:1968978-Feces,
pubmed-meshheading:1968978-Fimbriae, Bacterial,
pubmed-meshheading:1968978-Hemagglutination Tests,
pubmed-meshheading:1968978-Humans,
pubmed-meshheading:1968978-Infant,
pubmed-meshheading:1968978-Infant, Newborn,
pubmed-meshheading:1968978-Mannose,
pubmed-meshheading:1968978-Middle Aged,
pubmed-meshheading:1968978-Sepsis,
pubmed-meshheading:1968978-Serotyping,
pubmed-meshheading:1968978-Shiga Toxin 1,
pubmed-meshheading:1968978-Species Specificity,
pubmed-meshheading:1968978-Virulence
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Virulence factors of bacteraemic Escherichia coli with particular reference to production of cytotoxic necrotising factor (CNF) by P-fimbriate strains.
|
| pubmed:affiliation |
Departamento de Microbiología y Parasitología, Facultad de Veterinaria, Universidad de Santiago, Lugo, Spain.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|