|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
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|
pubmed:dateCreated |
2009-10-19
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|
pubmed:abstractText |
Progressive neurodegeneration may result in potentially severe cognitive and motor dysfunctions as a complication of Langerhans cell histiocytosis (LCH), a suggested IL-17A-associated inflammatory condition. To detect this complication (CNS-LCH) early and to evaluate the potential efficacy of therapeutic interventions, biomarkers detecting and measuring ongoing neurodegeneration would be valuable. We evaluated cerebrospinal fluid (CSF) biomarkers of ongoing neurodegeneration in CNS-LCH patients.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1545-5017
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
15
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1264-70
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pubmed:meshHeading |
pubmed-meshheading:19688833-Adolescent,
pubmed-meshheading:19688833-Biological Markers,
pubmed-meshheading:19688833-Brain,
pubmed-meshheading:19688833-Cerebrospinal Fluid Proteins,
pubmed-meshheading:19688833-Child,
pubmed-meshheading:19688833-Child, Preschool,
pubmed-meshheading:19688833-Cognition Disorders,
pubmed-meshheading:19688833-Disease Progression,
pubmed-meshheading:19688833-Female,
pubmed-meshheading:19688833-Follow-Up Studies,
pubmed-meshheading:19688833-Glial Fibrillary Acidic Protein,
pubmed-meshheading:19688833-Histiocytosis, Langerhans-Cell,
pubmed-meshheading:19688833-Humans,
pubmed-meshheading:19688833-Infant,
pubmed-meshheading:19688833-Male,
pubmed-meshheading:19688833-Nerve Degeneration,
pubmed-meshheading:19688833-Neurofilament Proteins,
pubmed-meshheading:19688833-Pituitary Diseases,
pubmed-meshheading:19688833-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19688833-Spinal Puncture,
pubmed-meshheading:19688833-Young Adult,
pubmed-meshheading:19688833-tau Proteins
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Biomarkers in the cerebrospinal fluid and neurodegeneration in Langerhans cell histiocytosis.
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|
pubmed:affiliation |
Department of Woman and Child Health, Childhood Cancer Research Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
