| pubmed-article:1968836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1968836 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1968836 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1968836 | lifeskim:mentions | umls-concept:C0040132 | lld:lifeskim |
| pubmed-article:1968836 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:1968836 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:1968836 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1968836 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1968836 | pubmed:dateCreated | 1990-4-23 | lld:pubmed |
| pubmed-article:1968836 | pubmed:abstractText | We have tested the potential role of thyroid cell intercellular adhesion molecule-1 (ICAM-1) expression by in vitro assays of cell clustering and cytotoxicity. Increased ICAM-1 appeared within 24 h of thyroid cell stimulation with cytokines and was not inhibited by the antithyroid drug methimazole. Autologous and allogeneic lymphocyte-thyroid cell cluster formation, assessed by flow cytometry, was reduced by about one-third in the presence of a monoclonal antibody against ICAM-1, regardless of whether thyroid cells were expressing basal levels of ICAM-1 or had been stimulated with interferon-gamma. The cytotoxicity produced by interleukin 2-stimulated allogeneic lymphocytes was not consistently inhibited by anti-ICAM-1 antibody, but phytohemagglutinin-stimulated lymphocytes showed a reduction of 23%-28% in cytotoxicity against untreated or interferon-gamma stimulated thyroid cells when the anti-ICAM-1 monoclonal antibody was present. Finally, thyroid cells could be infected by rhinovirus, confirming the presence of fully functional ligand. These results show that ICAM-1 expression by thyroid cells may enhance immune cell recognition and play some role in cytotoxicity, features which could be important in the initiation or perpetuation of autoimmune thyroiditis. | lld:pubmed |
| pubmed-article:1968836 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1968836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1968836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1968836 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1968836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1968836 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1968836 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1968836 | pubmed:author | pubmed-author:FreemanMM | lld:pubmed |
| pubmed-article:1968836 | pubmed:author | pubmed-author:WeetmanA PAP | lld:pubmed |
| pubmed-article:1968836 | pubmed:author | pubmed-author:MakgobaM WMW | lld:pubmed |
| pubmed-article:1968836 | pubmed:author | pubmed-author:BorysiewiczL... | lld:pubmed |
| pubmed-article:1968836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1968836 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:1968836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1968836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1968836 | pubmed:pagination | 271-5 | lld:pubmed |
| pubmed-article:1968836 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
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| pubmed-article:1968836 | pubmed:meshHeading | pubmed-meshheading:1968836-... | lld:pubmed |
| pubmed-article:1968836 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1968836 | pubmed:articleTitle | Functional analysis of intercellular adhesion molecule-1-expressing human thyroid cells. | lld:pubmed |
| pubmed-article:1968836 | pubmed:affiliation | Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Cambridge, GB. | lld:pubmed |
| pubmed-article:1968836 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1968836 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1968836 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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