Linked Life Data

1968836

Source:http://linkedlifedata.com/resource/pubmed/id/1968836

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-4-23
pubmed:abstractText
We have tested the potential role of thyroid cell intercellular adhesion molecule-1 (ICAM-1) expression by in vitro assays of cell clustering and cytotoxicity. Increased ICAM-1 appeared within 24 h of thyroid cell stimulation with cytokines and was not inhibited by the antithyroid drug methimazole. Autologous and allogeneic lymphocyte-thyroid cell cluster formation, assessed by flow cytometry, was reduced by about one-third in the presence of a monoclonal antibody against ICAM-1, regardless of whether thyroid cells were expressing basal levels of ICAM-1 or had been stimulated with interferon-gamma. The cytotoxicity produced by interleukin 2-stimulated allogeneic lymphocytes was not consistently inhibited by anti-ICAM-1 antibody, but phytohemagglutinin-stimulated lymphocytes showed a reduction of 23%-28% in cytotoxicity against untreated or interferon-gamma stimulated thyroid cells when the anti-ICAM-1 monoclonal antibody was present. Finally, thyroid cells could be infected by rhinovirus, confirming the presence of fully functional ligand. These results show that ICAM-1 expression by thyroid cells may enhance immune cell recognition and play some role in cytotoxicity, features which could be important in the initiation or perpetuation of autoimmune thyroiditis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-5
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Functional analysis of intercellular adhesion molecule-1-expressing human thyroid cells.
pubmed:affiliation
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Cambridge, GB.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't