Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-6-29
pubmed:databankReference
pubmed:abstractText
Dlk1 (Delta-like homolog 1) is a cell surface transmembrane glycoprotein belonging to the epidermal growth factor like family of homeotic proteins and plays an important role in regulating fetal and postnatal development. Increased expression of Dlk1 is the primary cause of muscle hypertrophy in the callipyge sheep exhibiting overgrowth of fast-twitch muscles and reduced adiposity. However, the function of Dlk1 in goats remains unknown. In this study, a fragment of 864 bp of goat Dlk1 cDNA, encoding 287 amino acids, was amplified, which has a high homology both in nucleotide sequence and amino acid sequence with the corresponding region of pig, cattle and sheep Dlk1. The Dlk1 was found to be expressed in most tissues of goat fetuses, and in the adrenal gland, pancreas and thymus of adult goats. Two alternative transcripts of Dlk1-C and Dlk1-C2 were expressed in both fetuses and adult goats. One C/T transition in the coding region of goat Dlk1 was identified and by genotyping one segregating goat family and the expressed allele in the tissues of the offspring, Dlk1 was found to be paternally expressed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1573-4978
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2259-64
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Analysis on cDNA sequence, mRNA expression and imprinting status of Dlk1 gene in goats.
pubmed:affiliation
Laboratory of Animal Molecular Genetics, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 271018, Taian, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't