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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-26
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pubmed:abstractText |
Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterised by excessive tachycardia of unknown aetiology. Whether this condition involves abnormal cardiac sympathetic innervation or function remains elusive. Meta-iodobenzylguanidine (MIBG) resembles guanethidine and is a pharmacologically inactive analogue of norepinephrine, which is similarly metabolised in noradrenergic neurons. MIBG myocardial scintigraphy is used clinically to estimate local myocardial sympathetic nerve damage in some forms of heart disease and autonomic neuropathy. The objective of this study was to evaluate cardiac sympathetic innervation in patients with POTS.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1468-330X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-43
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pubmed:meshHeading |
pubmed-meshheading:19687022-3-Iodobenzylguanidine,
pubmed-meshheading:19687022-Adult,
pubmed-meshheading:19687022-Autonomic Nervous System Diseases,
pubmed-meshheading:19687022-Blood Pressure,
pubmed-meshheading:19687022-Diagnosis, Differential,
pubmed-meshheading:19687022-Electrocardiography,
pubmed-meshheading:19687022-Female,
pubmed-meshheading:19687022-Fourier Analysis,
pubmed-meshheading:19687022-Galvanic Skin Response,
pubmed-meshheading:19687022-Heart,
pubmed-meshheading:19687022-Heart Rate,
pubmed-meshheading:19687022-Humans,
pubmed-meshheading:19687022-Male,
pubmed-meshheading:19687022-Norepinephrine,
pubmed-meshheading:19687022-Postural Orthostatic Tachycardia Syndrome,
pubmed-meshheading:19687022-Radiopharmaceuticals,
pubmed-meshheading:19687022-Reference Values,
pubmed-meshheading:19687022-Signal Processing, Computer-Assisted,
pubmed-meshheading:19687022-Sympathetic Nervous System,
pubmed-meshheading:19687022-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2010
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pubmed:articleTitle |
Cardiac neurotransmission imaging with 123I-meta-iodobenzylguanidine in postural tachycardia syndrome.
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pubmed:affiliation |
Department of Neurology, Autonomic Laboratory, HELIOS Klinikum Wuppertal, University of Witten/Herdecke, Heusnerstr 40, D-42283 Wuppertal, Germany. carl-albrecht.haensch@helios-kliniken.de
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pubmed:publicationType |
Journal Article
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