Linked Life Data

19686806

Source:http://linkedlifedata.com/resource/pubmed/id/19686806

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-11-2
pubmed:abstractText
To investigate the mechanisms underlying impaired hippocampal function resulting from masticatory dysfunction, we examined the effects of the molarless condition on cell proliferation and the effect of the administration of metyrapone, which suppresses the stress-induced rise in plasma corticosterone levels, on cell proliferation in the hippocampal dentate gyrus (DG) of aged senescence-accelerated prone (SAMP8) mice. In addition, we examined whether chewing under restraint stress prevents the stress-induced suppression of cell proliferation. In aged mice, the molarless condition suppressed cell proliferation in the hippocampal DG. Vehicle-injected molarless mice had significantly higher plasma corticosterone levels than vehicle-injected control and metyrapone-injected molarless mice, in association with decreased cell proliferation in the hippocampal DG. Pretreatment with metyrapone inhibited the increase in plasma corticosterone levels induced by the bite-raised condition, and also attenuated the reduction in cell proliferation. Immobilization stress suppressed cell proliferation in the hippocampal DG, but chewing under restraint stress blocked the stress-induced suppression of cell proliferation in the DG. These results suggest that the morphologic deficits induced by the molarless condition in aged SAMP8 mice are a result of increased plasma corticosterone levels, and that chewing under restraint stress prevents the stress-induced suppression of cell birth in the DG.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-7972
pubmed:author
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
466
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Chewing under restraint stress inhibits the stress-induced suppression of cell birth in the dentate gyrus of aged SAMP8 mice.
pubmed:affiliation
Seijoh University Graduate School of Health Care Studies, 2-172 Fukinodai, Tokai, Aichi 476-8588, Japan. kubo@seijoh-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't