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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-8-18
pubmed:abstractText
Patterning of the primitive foregut promotes appropriate organ specification along its anterior-posterior axis. However, the molecular pathways specifying foregut endoderm progenitors are poorly understood. We show here that Wnt2/2b signaling is required to specify lung endoderm progenitors within the anterior foregut. Embryos lacking Wnt2/2b expression exhibit complete lung agenesis and do not express Nkx2.1, the earliest marker of the lung endoderm. In contrast, other foregut endoderm-derived organs, including the thyroid, liver, and pancreas, are correctly specified. The phenotype observed is recapitulated by an endoderm-restricted deletion of beta-catenin, demonstrating that Wnt2/2b signaling through the canonical Wnt pathway is required to specify lung endoderm progenitors within the foregut. Moreover, activation of canonical Wnt/beta-catenin signaling results in the reprogramming of esophagus and stomach endoderm to a lung endoderm progenitor fate. Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-10401665, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-10545105, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-10706142, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-11262227, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-11358962, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-11914369, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12015971, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12142021, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12361974, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12399308, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12626757, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12865297, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12885771, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-12952940, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-15315763, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-15576401, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-15716345, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-15907834, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-16169491, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-16192304, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-16414041, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-16452165, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-16799568, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-17101329, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-17332475, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-17428829, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-17607356, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-18231602, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-18356571, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-18367557, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-18533146, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-8557195, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-8612983, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-8951051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-9545553, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-9731531, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-9784490, http://linkedlifedata.com/resource/pubmed/commentcorrection/19686689-9916808
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1878-1551
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
290-8
pubmed:dateRevised
2011-3-15
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut.
pubmed:affiliation
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't
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