Linked Life Data

19686207

Source:http://linkedlifedata.com/resource/pubmed/id/19686207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-8-18
pubmed:abstractText
Alzheimer's disease (AD) is a devastating neurodegenerative condition that affects more than 5 million Americans. Currently, a definitive and unequivocal diagnosis of AD can only be confirmed histopathogically via postmortem autopsy, demonstrating the need for objective measures of cognitive functioning for those at risk for AD. The single most important genetic risk factor of AD is the apolipoprotein E (ApoE) epsilon4 allele. The present study investigated olfactory and cognitive processing deficits in ApoE epsilon4(+) individuals using a cross-modal recognition memory task and an objective electrophysiological measure, the event-related potential (ERP). Ten epsilon4(+) individuals (5 M, 5 F, mean [M]= 75.1 years) and 10 age- and gender-matched epsilon4(-) individuals (5 M, 5 F, M = 71 years) sequentially encoded a set of 16 olfactory stimuli and were subsequently shown names of odors previously presented (targets) or not (foils). EEG activity was recorded from 19 electrodes as participants distinguished targets from foils using a two-button mouse. P3 latencies were significantly longer in epsilon4(+) individuals, and intraclass correlations demonstrated differential activity between the two groups. These findings are consistent with a compensatory hypothesis, which posits that nondemented epsilon4(+) individuals will expend greater effort in cognitive processing or engage in alternative strategies and therefore require greater activation of neural tissue or recruitment of different neural populations. The findings also suggest that cross-modal ERP studies of recognition memory discriminate early neurocognitive changes in ApoE epsilon4(+) and ApoE epsilon4(-) individuals and may contribute to identifying the phenotype of persons who will develop Alzheimer's disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
647-57
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Olfaction in aging and Alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate ApoE epsilon4+ and ApoE epsilon 4- individuals.
pubmed:affiliation
San Diego State University, San Diego, California 92120-4913, USA. cmurphy@sciences.sdsu.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural