Linked Life Data

19686115

Source:http://linkedlifedata.com/resource/pubmed/id/19686115

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-8-18
pubmed:abstractText
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that underlies the augmented insulin release from the pancreas in response to glucose in the gut lumen more than to intravenous injected glucose (the "incretin effect"). GLP-1, found in enteroendocrine L cells of the gut, regulates appetite and gut motility and is released from L cells in response to glucose. GLP-1-expressing duodenal L cells also express T1r taste receptors, alpha-gustducin, and many other taste transduction elements. Knockout mice lacking alpha-gustducin or T1r3 have deficiencies in secretion of GLP-1 and in the regulation of plasma levels of insulin and glucose. Gut-expressed taste-signaling elements underlie multiple chemosensory functions of the gut including the incretin effect. Modulating hormone secretion from gut "taste cells" may provide novel treatments for obesity, diabetes, and malabsorption.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-4
pubmed:dateRevised
2011-10-25
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.
pubmed:affiliation
Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA.
pubmed:publicationType
Journal Article