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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-9
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pubmed:abstractText |
The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 mg/kg of 9-AC equivalent every other day for 6 weeks, resulted in regression of tumors in 9 of 10 mice. A lower dose of P-9-AC (1.25 mg/kg of 9-AC equivalent) every other day for 8 weeks inhibited subcutaneous tumor growth in all mice. No liver metastases were observed. Colon-specific release of 9-AC from polymer conjugates enhanced antitumor activity and minimized the systemic toxicity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1616-5195
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1135-42
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pubmed:meshHeading |
pubmed-meshheading:19685500-Animals,
pubmed-meshheading:19685500-Antineoplastic Agents,
pubmed-meshheading:19685500-Biocompatible Materials,
pubmed-meshheading:19685500-Camptothecin,
pubmed-meshheading:19685500-Cell Line, Tumor,
pubmed-meshheading:19685500-Colonic Neoplasms,
pubmed-meshheading:19685500-Drug Carriers,
pubmed-meshheading:19685500-Drug Delivery Systems,
pubmed-meshheading:19685500-Female,
pubmed-meshheading:19685500-Humans,
pubmed-meshheading:19685500-Male,
pubmed-meshheading:19685500-Materials Testing,
pubmed-meshheading:19685500-Methacrylates,
pubmed-meshheading:19685500-Mice,
pubmed-meshheading:19685500-Mice, Nude,
pubmed-meshheading:19685500-Molecular Structure,
pubmed-meshheading:19685500-Neoplasm Transplantation,
pubmed-meshheading:19685500-Polymers,
pubmed-meshheading:19685500-Survival Rate,
pubmed-meshheading:19685500-Transplantation, Heterologous,
pubmed-meshheading:19685500-Xenograft Model Antitumor Assays
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pubmed:year |
2009
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pubmed:articleTitle |
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
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pubmed:affiliation |
Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD, University of Utah, Salt Lake City, Utah 84112, USA.
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pubmed:publicationType |
Journal Article,
Evaluation Studies,
Research Support, N.I.H., Extramural
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