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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1990-4-5
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pubmed:abstractText |
We investigated the effects of beta 2- (procaterol 2 x 50 micrograms/day for 9 days) and beta 1- (xamoterol 2 x 200 mg/day for 14 days) adrenoceptor agonists on lymphocyte beta 2-adrenoceptor density and beta 1- and beta 2-adrenoceptor in vivo function (assessed as isoprenaline-infusion-evoked hemodynamic effects and exercise-induced tachycardia) in healthy volunteers. Procaterol decreased lymphocyte beta 2-adrenoceptor density and all beta 2-adrenoceptor-mediated in vivo effects but did not affect beta 1-adrenoceptor-mediated in vivo effects. In contrast, xamoterol neither affected lymphocyte beta 2-adrenoceptors nor beta 2-adrenoceptor-mediated in vivo effects but decreased beta 1-adrenoceptor-mediated in vivo effects. It is concluded that in humans, generally long-term application of beta 1- or beta 2-adrenoceptor agonists causes desensitization of beta-adrenoceptor function but in a beta-adrenoceptor subtype-selective fashion.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Procaterol,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Xamoterol
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-7322
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
914-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1968366-Adrenergic beta-Agonists,
pubmed-meshheading:1968366-Adult,
pubmed-meshheading:1968366-Blood Pressure,
pubmed-meshheading:1968366-Ethanolamines,
pubmed-meshheading:1968366-Exercise Test,
pubmed-meshheading:1968366-Heart Rate,
pubmed-meshheading:1968366-Humans,
pubmed-meshheading:1968366-Isoproterenol,
pubmed-meshheading:1968366-Lymphocytes,
pubmed-meshheading:1968366-Male,
pubmed-meshheading:1968366-Procaterol,
pubmed-meshheading:1968366-Propanolamines,
pubmed-meshheading:1968366-Receptors, Adrenergic, beta,
pubmed-meshheading:1968366-Tachyphylaxis,
pubmed-meshheading:1968366-Time Factors,
pubmed-meshheading:1968366-Xamoterol
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pubmed:year |
1990
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pubmed:articleTitle |
Agonist-induced desensitization of beta-adrenoceptor function in humans. Subtype-selective reduction in beta 1- or beta 2-adrenoceptor-mediated physiological effects by xamoterol or procaterol.
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pubmed:affiliation |
Biochemical Research Lab, University of Essen, FRG.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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