Linked Life Data

19683021

Source:http://linkedlifedata.com/resource/pubmed/id/19683021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-10-9
pubmed:abstractText
The organoselenium compound diphenyl diselenide (PhSe)(2) has shown interesting antioxidant and neuroprotective activities. On the other hand, this compound has also presented some toxic effects. m-Trifluoromethyl-diphenyl diselenide (m-CF(3)-C(6)H(4)Se)(2), a structural analog of (PhSe)(2), has proven to be antipsychotic and antioxidant in mice. The present study was designed to investigate the anxiolytic-like effect of (m-CF(3)-C(6)H(4)Se)(2) in female mice, employing light/dark box and elevated plus-maze (EPM) tests. The involvement of 5-hydroxytryptamine (5-HT) receptors and monoamine oxidase (MAO) activity in the anxiolytic-like effect was also evaluated. (m-CF(3)-C(6)H(4)Se)(2) (0.1, 10 and 100 mg/kg, p.o.) did not affect locomotor activity as evaluated in the open-field test (OFT). (m-CF(3)-C(6)H(4)Se)(2) at the dose of 100 mg/kg produced an anxiolytic-like action, both in light-dark box and the EPM tests. To evaluate the role of 5-HT receptors in the anxiolytic-like effect of (m-CF(3)-C(6)H(4)Se)(2), a selective 5-HT(1A) receptor antagonist, WAY100635 (0.1 mg/kg, s.c.), a non-selective 5-HT(2A/2C) receptor antagonist, ritanserin (2 mg/kg, i.p.) and a selective 5-HT(3) receptor antagonist, ondansetron (0.1 mg/kg, i.p.) were used. All the antagonists used were able to abolish the anxiolytic-like effect of (m-CF(3)-C(6)H(4)Se)(2). (m-CF(3)-C(6)H(4)Se)(2), at the dose of 100 mg/kg, inhibited the MAO-A activity in mice brain. Taken together these data demonstrated that the anxiolytic-like effect caused by (m-CF(3)-C(6)H(4)Se)(2) seems to be mediated by the involvement of the serotonergic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-7549
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
205
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
511-7
pubmed:meshHeading
pubmed-meshheading:19683021-Animals, pubmed-meshheading:19683021-Anti-Anxiety Agents, pubmed-meshheading:19683021-Anxiety, pubmed-meshheading:19683021-Brain, pubmed-meshheading:19683021-Dose-Response Relationship, Drug, pubmed-meshheading:19683021-Female, pubmed-meshheading:19683021-Lighting, pubmed-meshheading:19683021-Locomotion, pubmed-meshheading:19683021-Maze Learning, pubmed-meshheading:19683021-Mice, pubmed-meshheading:19683021-Monoamine Oxidase, pubmed-meshheading:19683021-Neuropsychological Tests, pubmed-meshheading:19683021-Ondansetron, pubmed-meshheading:19683021-Organosilicon Compounds, pubmed-meshheading:19683021-Piperazines, pubmed-meshheading:19683021-Pyridines, pubmed-meshheading:19683021-Random Allocation, pubmed-meshheading:19683021-Receptors, Serotonin, pubmed-meshheading:19683021-Ritanserin, pubmed-meshheading:19683021-Serotonin Antagonists
pubmed:year
2009
pubmed:articleTitle
Involvement of the serotonergic system in the anxiolytic-like effect caused by m-trifluoromethyl-diphenyl diselenide in mice.
pubmed:affiliation
Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't