Source:http://linkedlifedata.com/resource/pubmed/id/19682895
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
|
| pubmed:dateCreated |
2009-8-26
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| pubmed:abstractText |
Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 microM against Mycobacterium tuberculosis H37Rv.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5372-5
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| pubmed:meshHeading |
pubmed-meshheading:19682895-Antitubercular Agents,
pubmed-meshheading:19682895-Diamines,
pubmed-meshheading:19682895-Microbial Sensitivity Tests,
pubmed-meshheading:19682895-Mycobacterium tuberculosis,
pubmed-meshheading:19682895-Structure-Activity Relationship,
pubmed-meshheading:19682895-Tuberculosis
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Synthesis of novel [1,2]-diamines with antituberculosis activity.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
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| pubmed:publicationType |
Journal Article
|