Source:http://linkedlifedata.com/resource/pubmed/id/19682579
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2009-11-16
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| pubmed:abstractText |
Kidney ischemia-reperfusion injury (IRI) is an important contributor to delayed graft function (DGF) and poor outcome of allografts. Small clinical studies suggest a beneficial role for human anti-thymocyte globulin (ATG) in DGF. We investigated the short-term effect of mouse anti-thymocyte globulin (mATG) on kidney warm IRI in mice. We administered either mATG, rabbit immunoglobulin (RIgG), or saline with different dosing schedules in three different IRI models: 30 min bilateral, 60 min bilateral, and 45min unilateral IRI. mATG effectively depleted circulating T cells but had less effect on kidney-infiltrating T cells. There was no difference in serum creatinine levels between groups in each study. Scoring of renal tubular damage and regenerating tubules revealed no difference between groups. The percentage of CD3(+)CD4(-)CD8(-) double-negative (DN) T cells, which were reported to contribute to the pathogenesis of lupus nephritis, increased and the percentages of regulatory T cells and NK cells decreased in the post-ischemic kidneys of mATG treated mice. mATG did not alter the expression of pro-inflammatory cytokines such as IFN-gamma or anti-inflammatory cytokines such as IL-10 in post-ischemic kidneys. mATG treatment, whether initiated before ischemia or immediately after reperfusion, had minimal effects on renal injury following warm IRI in mice.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antilymphocyte Serum,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1878-5492
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
44-54
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| pubmed:meshHeading |
pubmed-meshheading:19682579-Animals,
pubmed-meshheading:19682579-Antilymphocyte Serum,
pubmed-meshheading:19682579-Blood Cell Count,
pubmed-meshheading:19682579-Chemokines,
pubmed-meshheading:19682579-Creatinine,
pubmed-meshheading:19682579-Cytokines,
pubmed-meshheading:19682579-Immunoglobulin G,
pubmed-meshheading:19682579-Kidney,
pubmed-meshheading:19682579-Kidney Cortex,
pubmed-meshheading:19682579-Kidney Medulla,
pubmed-meshheading:19682579-Kidney Tubules,
pubmed-meshheading:19682579-Lymphocyte Depletion,
pubmed-meshheading:19682579-Lymphocyte Subsets,
pubmed-meshheading:19682579-Male,
pubmed-meshheading:19682579-Mice,
pubmed-meshheading:19682579-Mice, Inbred C57BL,
pubmed-meshheading:19682579-Rabbits,
pubmed-meshheading:19682579-Reperfusion Injury,
pubmed-meshheading:19682579-Spleen,
pubmed-meshheading:19682579-Survival Rate,
pubmed-meshheading:19682579-T-Lymphocytes
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| pubmed:year |
2009
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| pubmed:articleTitle |
The effect of murine anti-thymocyte globulin on experimental kidney warm ischemia-reperfusion injury in mice.
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| pubmed:affiliation |
Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. shinehr@gmail.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|