Linked Life Data

19682082

Source:http://linkedlifedata.com/resource/pubmed/id/19682082

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-17
pubmed:abstractText
Organoselenium compounds display important antioxidant activity and many biological activities interesting from pharmacological point of view. The aim of this study was to evaluate the hepatoprotective effect of p-methoxyl-diphenyl diselenide, a disubstituted diaryl diselenide, on acute liver injury induced by D-galactosamine (D-GalN) and lipopolysaccharide (LPS) in mice. The animals received p-methoxyl-diphenyl diselenide (10, 50 and 100 mg/kg; per oral, p.o.) and 1 h after d-GalN (500 mg/kg) and LPS (50 microg/kg) were administered by intraperitoneal route (i.p.). Twenty-four hours after LPS/d-GalN exposure the animals were euthanized to the biochemical and histological analysis. Pretreatment with p-methoxyl-diphenyl diselenide (50 and 100 mg/kg; p.o.) protected against the increase in aspartate aminotransferase (AST) activity induced by LPS/d-GalN exposure in mice. p-Methoxyl-diphenyl diselenide at the doses of 50 and 100 mg/kg protected against the increase in alanine aminotransferase (ALT) activity induced by LPS/D-GalN exposure. In this study, no alteration in ascorbic acid levels was observed in livers of mice exposed to LPS/D-GalN. Glutathione-S-transferase (GST) activity was stimulated by LPS/D-GalN exposure and p-methoxyl-diphenyl diselenide, at all doses, protected against this alteration. p-Methoxyl-diphenyl diselenide was effective in ameliorating inhibition of catalase activity induced by LPS/d-GalN exposure. Histological data showed that sections of livers from LPS/D-GalN-treated mice presented massive hemorrhage, inflammatory cells and necrosis. p-Methoxyl-diphenyl diselenide significantly attenuated LPS/D-GalN-induced hepatic histopathological alterations. Based on the results, we suggest the hepatoprotective effect of p-methoxyl-diphenyl diselenide on acute liver injury induced by LPS/d-GalN exposure in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1472-8206
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
727-34
pubmed:meshHeading
pubmed-meshheading:19682082-Administration, Oral, pubmed-meshheading:19682082-Alanine Transaminase, pubmed-meshheading:19682082-Animals, pubmed-meshheading:19682082-Antioxidants, pubmed-meshheading:19682082-Ascorbic Acid, pubmed-meshheading:19682082-Aspartate Aminotransferases, pubmed-meshheading:19682082-Benzene Derivatives, pubmed-meshheading:19682082-Catalase, pubmed-meshheading:19682082-Dose-Response Relationship, Drug, pubmed-meshheading:19682082-Drug-Induced Liver Injury, pubmed-meshheading:19682082-Galactosamine, pubmed-meshheading:19682082-Glutathione Transferase, pubmed-meshheading:19682082-Injections, Intraperitoneal, pubmed-meshheading:19682082-Lipopolysaccharides, pubmed-meshheading:19682082-Liver Failure, Acute, pubmed-meshheading:19682082-Male, pubmed-meshheading:19682082-Mice, pubmed-meshheading:19682082-Organoselenium Compounds
pubmed:year
2009
pubmed:articleTitle
Protective effect of p-methoxyl-diphenyl diselenide in lethal acute liver failure induced by lipopolysaccharide and D-galactosamine in mice.
pubmed:affiliation
Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't