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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-3-24
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pubmed:abstractText |
Idiopathic epilepsy is caused by the complex interaction of genetic and environmental factors. The purpose of this study was to use computational approaches to explore the interaction between changes in sodium channel availability caused by mutations and mossy fiber sprouting.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-1167
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
136-45
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pubmed:meshHeading |
pubmed-meshheading:19682031-Action Potentials,
pubmed-meshheading:19682031-Animals,
pubmed-meshheading:19682031-Calcium Channels, N-Type,
pubmed-meshheading:19682031-Computer Simulation,
pubmed-meshheading:19682031-Dentate Gyrus,
pubmed-meshheading:19682031-Electric Stimulation,
pubmed-meshheading:19682031-Epilepsy, Temporal Lobe,
pubmed-meshheading:19682031-Excitatory Postsynaptic Potentials,
pubmed-meshheading:19682031-Humans,
pubmed-meshheading:19682031-Ion Channel Gating,
pubmed-meshheading:19682031-Membrane Potentials,
pubmed-meshheading:19682031-Mossy Fibers, Hippocampal,
pubmed-meshheading:19682031-Mutation,
pubmed-meshheading:19682031-Neural Inhibition,
pubmed-meshheading:19682031-Neural Networks (Computer),
pubmed-meshheading:19682031-Neurons,
pubmed-meshheading:19682031-Patch-Clamp Techniques,
pubmed-meshheading:19682031-Perforant Pathway,
pubmed-meshheading:19682031-Rats,
pubmed-meshheading:19682031-Seizures,
pubmed-meshheading:19682031-Sodium Channel Blockers,
pubmed-meshheading:19682031-Sodium Channels,
pubmed-meshheading:19682031-Synaptic Transmission
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pubmed:year |
2010
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pubmed:articleTitle |
Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability.
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pubmed:affiliation |
Howard Florey Institute, Parkville, Victoria, Australia. evan@evan-thomas.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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