Source:http://linkedlifedata.com/resource/pubmed/id/19681973
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-10-5
|
| pubmed:abstractText |
Renin-angiotensin-aldosterone system (RAAS) polymorphisms such as the angiotensinogen-gene-M235T-, the angiotensin-conversion enzyme (ACE)-gene I/D- and the angiotensin-II-type 1-receptor-(AT1R)-A1166C-polymorphism have been implicated in renal insufficiency and hypertension. We studied the association of these RAAS genotypes and non-genetic factors with transplant function and hypertension after renal graft transplantation (NTX). A total of 229 renal graft recipients, transplanted at a single center, were monitored up to 54 months and genotyped using polymerase chain reaction. The prevalence of the genotypes was comparable to a control group of healthy volunteers. Genotype and clinical outcome was analyzed using ANOVA, while the k-nearest neighbor method was used for a pattern recognition analysis of the complete database. Hypertension after NTX was not influenced by the RAAS polymorphisms. The DD-genotype of the ACE-I/D-polymorphism was associated with significantly deteriorated renal transplant function during the months 18 to 30 after transplantation according to ANOVA at p < 0.05, as were non-genetic factors like long hospitalization, poor primary transplant function, and frequent rejections. Pattern recognition identified, the use of cyclosporine (odds ratio of 4.25) and the use of Ang II-receptor-blockers at discharge indicating the need of effective antihypertensive treatment (odds ratio of 3.26) as risk factors for transplant function loss. Altogether, the significant impact of the DD-genotype on the outcome after renal transplantation emphasizes the early identification of RAAS genotypes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1399-0012
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
23
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
606-15
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| pubmed:meshHeading |
pubmed-meshheading:19681973-Adult,
pubmed-meshheading:19681973-Angiotensinogen,
pubmed-meshheading:19681973-Case-Control Studies,
pubmed-meshheading:19681973-Female,
pubmed-meshheading:19681973-Genotype,
pubmed-meshheading:19681973-Graft Rejection,
pubmed-meshheading:19681973-Humans,
pubmed-meshheading:19681973-Hypertension,
pubmed-meshheading:19681973-Kidney Failure, Chronic,
pubmed-meshheading:19681973-Kidney Transplantation,
pubmed-meshheading:19681973-Male,
pubmed-meshheading:19681973-Middle Aged,
pubmed-meshheading:19681973-Peptidyl-Dipeptidase A,
pubmed-meshheading:19681973-Phenotype,
pubmed-meshheading:19681973-Polymorphism, Genetic,
pubmed-meshheading:19681973-Prognosis,
pubmed-meshheading:19681973-Receptor, Angiotensin, Type 1,
pubmed-meshheading:19681973-Renin-Angiotensin System,
pubmed-meshheading:19681973-Risk Factors,
pubmed-meshheading:19681973-Survival Rate,
pubmed-meshheading:19681973-Treatment Outcome
|
| pubmed:articleTitle |
Impact of genetic polymorphisms of the renin-angiotensin system and of non-genetic factors on kidney transplant function--a single-center experience.
|
| pubmed:affiliation |
Klinik fuer Nephrologie, Heinrich-Heine Universitaet Duesseldorf, Dusseldorf, Germany.
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| pubmed:publicationType |
Journal Article,
Clinical Trial
|