|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-2-18
|
|
pubmed:abstractText |
A previously developed semi-physiological model of chemotherapy-induced myelosuppression has shown consistent system-related parameter and inter-individual variability (IIV) estimates across drugs. A requirement for dose individualization to be useful is relatively low variability between treatment courses (inter-occasion variability [IOV]) in relation to IIV. The objective of this study was to evaluate and compare magnitudes of IOV and IIV in myelosuppression model parameters across six different anti-cancer drug treatments.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1432-0843
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
839-48
|
|
pubmed:meshHeading |
pubmed-meshheading:19680655-Antineoplastic Agents,
pubmed-meshheading:19680655-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19680655-Bone Marrow,
pubmed-meshheading:19680655-Cell Count,
pubmed-meshheading:19680655-Cell Enlargement,
pubmed-meshheading:19680655-Cell Proliferation,
pubmed-meshheading:19680655-Dose-Response Relationship, Drug,
pubmed-meshheading:19680655-Epirubicin,
pubmed-meshheading:19680655-Etoposide,
pubmed-meshheading:19680655-Fluorouracil,
pubmed-meshheading:19680655-Humans,
pubmed-meshheading:19680655-Individualized Medicine,
pubmed-meshheading:19680655-Models, Biological,
pubmed-meshheading:19680655-Myelopoiesis,
pubmed-meshheading:19680655-Neoplasms,
pubmed-meshheading:19680655-Neutrophils,
pubmed-meshheading:19680655-Observation,
pubmed-meshheading:19680655-Paclitaxel,
pubmed-meshheading:19680655-Taxoids,
pubmed-meshheading:19680655-Topotecan
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression.
|
|
pubmed:affiliation |
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden. emma.hansson@farmbio.uu.se
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
