Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-8
pubmed:abstractText
Background Pediatric follicular lymphoma has recently been recognized as a novel variant of follicular lymphoma in the World Health Organization classification of lymphomas. Given the rarity of the disease, histopathological and genetic data on this type of lymphoma are still scarce. DESIGN AND METHODS: We analyzed 25 cases of pediatric follicular lymphoma (patients aged <or=18 years) by morphology, immunohistochemistry and interphase fluorescence in situ hybridization. All patients analyzed were treated within Non-Hodgkin's Lymphoma--Berlin-Frankfurt-Münster (NHL-BFM) multicenter trials, and the cohort was representative of the German population. RESULTS: The genetic hallmark of adult follicular lymphoma, t(14;18)(q32;q21), was not detectable in any of the pediatric cases, although BCL2 protein was expressed in 55% of the latter cases. No correlation was found between BCL2 protein expression and outcome. Chromosomal breaks in the immunoglobulin heavy chain gene (IGH) and the BCL6 locus were detected in 5 of 17 and 1 of 18 cases, respectively. Patients with pediatric follicular lymphoma had long event-free survival and, in contrast to adult follicular lymphoma, the clinical course was not dominated by relapses. A simultaneous diffuse large B-cell lymphoma was frequently detected at initial diagnosis in children but did not indicate an aggressive clinical course. Conclusions Our data suggest that pediatric follicular lymphoma is a disease that differs from its adult counterpart both genetically and clinically.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-10193956, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-10552938, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-11877266, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-14671650, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-14982884, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-15016643, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-15238420, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-15486066, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-15690646, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-1640726, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-16424389, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-16645199, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-17485708, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-18492111, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-18509088, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-18537979, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-18838711, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-19030176, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-19123728, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-2194214, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-376087, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-7028244, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-7414342, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-7844597, http://linkedlifedata.com/resource/pubmed/commentcorrection/19679882-9792312
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1592-8721
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-9
pubmed:dateRevised
2010-9-24
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Pediatric follicular lymphoma--a clinico-pathological study of a population-based series of patients treated within the Non-Hodgkin's Lymphoma--Berlin-Frankfurt-Munster (NHL-BFM) multicenter trials.
pubmed:affiliation
1Department of Pathology, Hematopathology Section and Lymph Node Registry, Christian-Albrechts University, Kiel, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study