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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-28
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pubmed:abstractText |
Identification of subclinical atherosclerosis by ultrasonographic measurement of carotid intima-media thickness (IMT) is a validated tool, in conjunction with traditional risk factors, for clinical assessment of cardiovascular disease risk. IMT has also been recognized as a quantitative measure of cardiovascular disease progression in asymptomatic individuals, and many candidate gene association studies have attempted to identify genetic variants associated with interindividual differences in IMT with limited success. We sought to test the association between subclinical atherosclerosis measured by IMT and approximately 50,000 SNPs, densely mapping approximately 2100 genes found on the gene-centric Illumina cardiovascular disease beadchip in a multi-ethnic population-based sample.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3173-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19679847-Adult,
pubmed-meshheading:19679847-Aged,
pubmed-meshheading:19679847-Asian Continental Ancestry Group,
pubmed-meshheading:19679847-Carotid Arteries,
pubmed-meshheading:19679847-Carotid Stenosis,
pubmed-meshheading:19679847-Continental Population Groups,
pubmed-meshheading:19679847-DNA Mutational Analysis,
pubmed-meshheading:19679847-European Continental Ancestry Group,
pubmed-meshheading:19679847-Female,
pubmed-meshheading:19679847-Genetic Predisposition to Disease,
pubmed-meshheading:19679847-Genetic Testing,
pubmed-meshheading:19679847-Histone Deacetylases,
pubmed-meshheading:19679847-Humans,
pubmed-meshheading:19679847-Male,
pubmed-meshheading:19679847-Middle Aged,
pubmed-meshheading:19679847-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19679847-Polymorphism, Single Nucleotide,
pubmed-meshheading:19679847-Receptors, Atrial Natriuretic Factor,
pubmed-meshheading:19679847-Repressor Proteins,
pubmed-meshheading:19679847-Risk Factors,
pubmed-meshheading:19679847-Tunica Intima,
pubmed-meshheading:19679847-Ultrasonography
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pubmed:year |
2009
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pubmed:articleTitle |
Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray.
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pubmed:affiliation |
Robarts Research Institute and Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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