| pubmed-article:1967982 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0008109 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0242303 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1967982 | lifeskim:mentions | umls-concept:C0805701 | lld:lifeskim |
| pubmed-article:1967982 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1967982 | pubmed:dateCreated | 1990-3-28 | lld:pubmed |
| pubmed-article:1967982 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1967982 | pubmed:abstractText | The gene (E2A) for enhancer binding transcription factors E12 and E47 maps to the t(1;19) chromosomal translocation breakpoint in pre-B cell leukemias. Altered E2A transcripts lacking sequences coding for the helix-loop-helix DNA binding motif were detected in several t(1;19)-carrying cell lines. Fusion cDNAs that crossed the t(1;19) breakpoint were cloned and shown to code for an 85 kd protein consisting of the amino-terminal two-thirds of E2A fused to a chromosome 1-derived protein. The fusion protein has the features of a chimeric transcription factor in which the DNA binding domain of E2A is replaced by the putative DNA binding domain of a homeoprotein from chromosome 1 for which the name Prl (pre-B cell leukemia) is proposed. Identical E2A-prl mRNA junctions were detected by PCR in three t(1;19)-carrying cell lines, indicating that the fusion transcripts and predicted chimeric protein are a consistent feature of this translocation. | lld:pubmed |
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| pubmed-article:1967982 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1967982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1967982 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1967982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1967982 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1967982 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:GaliliNN | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:ClearyM LML | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:SmithS DSD | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:WilkinsonJJ | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:NourseJJ | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:StanbridgeEE | lld:pubmed |
| pubmed-article:1967982 | pubmed:author | pubmed-author:MellentinJ... | lld:pubmed |
| pubmed-article:1967982 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1967982 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:1967982 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:1967982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1967982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1967982 | pubmed:pagination | 535-45 | lld:pubmed |
| pubmed-article:1967982 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1967982 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1967982 | pubmed:articleTitle | Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. | lld:pubmed |
| pubmed-article:1967982 | pubmed:affiliation | Department of Pathology, Stanford University School of Medicine, California 94305. | lld:pubmed |
| pubmed-article:1967982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1967982 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1967982 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1967982 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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