Source:http://linkedlifedata.com/resource/pubmed/id/19679415
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-5-4
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| pubmed:abstractText |
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently clinicoradiologically-established encephalopathy syndrome. In the present study, we examined the levels of cerebrospinal fluid (CSF) tau protein, a marker of axonal damage, in 11 patients with AESD. CSF tau levels were normal on day 1 and increased from day 3 of the disease between the initial and the secondary seizures. Magnetic resonance imaging (MRI) reveals reduced diffusion in the subcortical white matter during days 3-7. Two patients showed elevated tau protein prior to the diffusion abnormality of subcortical white matter on MRI. Levels of CSF neuron specific enolase (NSE), a neuronal marker, were elevated in only two out of seven patients with AESD, and CSF tau levels were also increased in these patients. Our results indicated that tau protein is a more sensitive marker than NSE and axonal damage causes the conspicuous MRI findings in AESD patients. A therapeutic strategy for axonal protection should be developed to prevent severe neurological impairment of AESD patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
1872-7131
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
435-9
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| pubmed:meshHeading |
pubmed-meshheading:19679415-Acute Disease,
pubmed-meshheading:19679415-Adolescent,
pubmed-meshheading:19679415-Age Factors,
pubmed-meshheading:19679415-Axons,
pubmed-meshheading:19679415-Brain,
pubmed-meshheading:19679415-Brain Diseases,
pubmed-meshheading:19679415-Child,
pubmed-meshheading:19679415-Child, Preschool,
pubmed-meshheading:19679415-Diffusion,
pubmed-meshheading:19679415-Diffusion Magnetic Resonance Imaging,
pubmed-meshheading:19679415-Female,
pubmed-meshheading:19679415-Humans,
pubmed-meshheading:19679415-Infant,
pubmed-meshheading:19679415-Kinetics,
pubmed-meshheading:19679415-Magnetic Resonance Imaging,
pubmed-meshheading:19679415-Male,
pubmed-meshheading:19679415-Nerve Fibers, Myelinated,
pubmed-meshheading:19679415-Phosphopyruvate Hydratase,
pubmed-meshheading:19679415-Seizures,
pubmed-meshheading:19679415-Time Factors,
pubmed-meshheading:19679415-tau Proteins
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| pubmed:year |
2010
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| pubmed:articleTitle |
The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion.
|
| pubmed:affiliation |
Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, Fuchu, Tokyo 183-0042, Japan. Naoyuki_Tanuma@member.metro.tokyo.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|