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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-2-14
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pubmed:abstractText |
The role of B cells in induction of phenotypic and functional abnormalities of T cells in a murine retrovirus-induced immunodeficiency syndrome, MAIDS, was evaluated in mice depleted of mature B cells from birth with anti-IgM antibodies (mu-suppressed) and infected at 4 wk of age. Multicolor FACS analyses of CD4+ T cell subsets showed that development of phenotypic abnormalities of these cells at 9 wk after infection was completely inhibited by mu-suppression. Furthermore, induction of impaired proliferative responses to Con A and alloantigens and CTL responses to alloantigens was fully blocked in antibody-treated animals. The extent of virus replication was comparable in spleens of untreated and mu-suppressed mice. Retroviral induction of T cell dysfunction in MAIDS is thus dependent on the presence of B cells, and high level virus expression in mice without B cells has little or no effect on T cell function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2464640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2536830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2542949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2545779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2653373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2830334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2842430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2903214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-2984305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-3004990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-3027368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-3035057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-3277274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-3908182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-6230388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-6984001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1967300-7264563
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1967300-Animals,
pubmed-meshheading:1967300-Antigens, CD4,
pubmed-meshheading:1967300-B-Lymphocytes,
pubmed-meshheading:1967300-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1967300-Cells, Cultured,
pubmed-meshheading:1967300-Concanavalin A,
pubmed-meshheading:1967300-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1967300-Immunoglobulin M,
pubmed-meshheading:1967300-Immunologic Deficiency Syndromes,
pubmed-meshheading:1967300-Leukemia Virus, Murine,
pubmed-meshheading:1967300-Lymphocyte Activation,
pubmed-meshheading:1967300-Mice,
pubmed-meshheading:1967300-Mice, Inbred BALB C,
pubmed-meshheading:1967300-Mice, Inbred C57BL,
pubmed-meshheading:1967300-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1967300-Tumor Virus Infections
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pubmed:year |
1990
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pubmed:articleTitle |
B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome.
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pubmed:affiliation |
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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