Linked Life Data

1967214

Source:http://linkedlifedata.com/resource/pubmed/id/1967214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-9
pubmed:abstractText
We tested a population of over 60 patients with chronic myelogenous leukemia (CML) for changes in the structure and expression of the p53 gene, which is located on chromosome 17. Six of 27 (22%) blast crisis samples and 3 of 5 (60%) accelerated phase samples had rearrangements of chromosome 17, whereas only 3 of 42 (7%) chronic phase patients had cytogenetic changes in chromosome 17. There was no loss of heterozygosity during the transition to blastic crisis among seven individuals who were informative for polymorphic probes for regions in or around the p53 gene on 17p. One patient in the chronic phase and one patient in the blastic phase of the 61 CML patients studied exhibited rearrangements of the p53 gene that were detectable by Southern analysis. One p53 allele was rearranged in the chronic phase patient and both p53 alleles were rearranged in the blastic phase patient. The p53 messenger RNA (mRNA) was of normal size (2.8 kb) in chronic phase and blast crisis, and the expression of the p53 gene was at least as high or higher in blast crisis as in the chronic phase of CML. The high incidence of abnormalities of chromosome 17 in blast-crisis CML found in our studies and the discovery of rearrangements of the p53 gene in two CML patients studied suggest that further study with probes for the p53 gene and anonymous polymorphic sites in chromosome 17 should be conducted in CML.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
180-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:1967214-Blast Crisis, pubmed-meshheading:1967214-Blotting, Northern, pubmed-meshheading:1967214-Blotting, Southern, pubmed-meshheading:1967214-Chromosomes, Human, Pair 17, pubmed-meshheading:1967214-Gene Expression Regulation, Neoplastic, pubmed-meshheading:1967214-Gene Rearrangement, pubmed-meshheading:1967214-Genes, Neoplasm, pubmed-meshheading:1967214-Humans, pubmed-meshheading:1967214-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:1967214-Oncogene Proteins, pubmed-meshheading:1967214-Phosphoproteins, pubmed-meshheading:1967214-Polymorphism, Restriction Fragment Length, pubmed-meshheading:1967214-Proto-Oncogene Proteins, pubmed-meshheading:1967214-Proto-Oncogene Proteins c-myc, pubmed-meshheading:1967214-RNA, Messenger, pubmed-meshheading:1967214-RNA, Neoplasm, pubmed-meshheading:1967214-Tumor Suppressor Protein p53
pubmed:year
1990
pubmed:articleTitle
Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia.
pubmed:affiliation
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't