Source:http://linkedlifedata.com/resource/pubmed/id/19671092
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2010-5-17
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| pubmed:abstractText |
In order to determine long-term outcome, including survival, growth and development, following liver transplantation in children with metabolic disorders, we retrospectively reviewed charts of 54 children with metabolic disorders evaluated from 1989-2005 for presenting symptoms, transplantation timing and indications, survival, metabolic parameters, growth, and development. Thirty-three patients underwent liver transplantation (12 received combined liver-kidney transplants) at a median age of 21 months. At a median follow-up of 3.6 yr, patient survival was 100%, and liver and kidney allograft survival was 92%, and 100%, respectively. For the group as a whole, weight Z scores improved and body mass index at follow-up was in the normal range. Two yr post-transplantation, psychomotor development improved significantly (p < 0.01), but mental skills did not; however, both indices were in the low-normal range of development. When compared to patients with biliary atresia, children with metabolic disorders showed significantly lower mental developmental scores at one and two yr post-transplantation (p < 0.05), but psychomotor developmental scores were not significantly different. We conclude that, in patients with metabolic disorders meeting indications for transplantation, liver transplantation or combined liver-kidney transplantation (for those with accompanying renal failure) is associated with excellent long-term survival, improved growth, and improved psychomotor development.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1399-3046
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
14
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
268-75
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| pubmed:meshHeading |
pubmed-meshheading:19671092-Child,
pubmed-meshheading:19671092-Child, Preschool,
pubmed-meshheading:19671092-Female,
pubmed-meshheading:19671092-Humans,
pubmed-meshheading:19671092-Infant,
pubmed-meshheading:19671092-Infant, Newborn,
pubmed-meshheading:19671092-Kidney Transplantation,
pubmed-meshheading:19671092-Liver Transplantation,
pubmed-meshheading:19671092-Male,
pubmed-meshheading:19671092-Metabolic Diseases,
pubmed-meshheading:19671092-Retrospective Studies,
pubmed-meshheading:19671092-Time Factors
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Long-term outcome following pediatric liver transplantation for metabolic disorders.
|
| pubmed:affiliation |
Department of Surgery, Stanford University, Stanford, CA, USA.
|
| pubmed:publicationType |
Journal Article
|