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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-28
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pubmed:abstractText |
Gastric cancer (GC) is 1 of the most common human cancers. Early detection remains the most promising approach to improving long-term survival of patients with GC. We previously performed Serial Analysis of Gene Expression (SAGE) on 4 primary GCs and identified several GC-specific genes including Reg IV. Of these genes, olfactomedin 4 (OLFM4, also known as GW112 or hGC-1) is a candidate gene for cancer-specific expression. In this study, we examined the expression of olfactomedin 4 in human GC by immunohistochemistry. We also assessed serum olfactomedin 4 levels in GC patients by enzyme-linked immunosorbent assay. 94 (56%) of 167 GC cases were positive for olfactomedin 4 by immunostaining. Olfactomedin 4 staining was observed more frequently in stage I/II cases than in stage III/IV cases. The serum olfactomedin 4 concentration in presurgical GC patients (n = 123, mean +/- SE, 36.3 +/- 3.5 ng/mL) was significantly higher than that in healthy individuals (n = 76, 16.6 +/- 1.6 ng/mL). In patients with stage I GC, the sensitivity of serum olfactomedin 4 (25%) and Reg IV (35%) was superior to that of CA19-9 (5%) or CEA (3%). Furthermore, in patients with stage I GC, the combination of olfactomedin 4 and Reg IV elevated the diagnostic sensitivity to 52%. These results suggest that serum olfactomedin 4 is a useful marker for GC and its measurement alone or in combination with Reg IV has utility in the early detection of GC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CA-19-9 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinoembryonic Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/OLFM4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/REG4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-0215
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pubmed:author |
pubmed-author:AnamiKatsuhiroK,
pubmed-author:HayashiTetsutaroT,
pubmed-author:ItoMasanoriM,
pubmed-author:MotoshitaJunichiJ,
pubmed-author:NoguchiTsuyoshiT,
pubmed-author:OharaShinyaS,
pubmed-author:OueNaohideN,
pubmed-author:SakamotoNaoyaN,
pubmed-author:SentaniKazuhiroK,
pubmed-author:TanakaShinjiS,
pubmed-author:YasuiWataruW,
pubmed-author:YoshidaKazuhiroK
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2383-92
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pubmed:meshHeading |
pubmed-meshheading:19670418-Adenocarcinoma,
pubmed-meshheading:19670418-Adult,
pubmed-meshheading:19670418-Aged,
pubmed-meshheading:19670418-Aged, 80 and over,
pubmed-meshheading:19670418-Animals,
pubmed-meshheading:19670418-Blotting, Western,
pubmed-meshheading:19670418-CA-19-9 Antigen,
pubmed-meshheading:19670418-Carcinoembryonic Antigen,
pubmed-meshheading:19670418-Carcinoma, Adenosquamous,
pubmed-meshheading:19670418-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19670418-Female,
pubmed-meshheading:19670418-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:19670418-Humans,
pubmed-meshheading:19670418-Immunoenzyme Techniques,
pubmed-meshheading:19670418-Lectins, C-Type,
pubmed-meshheading:19670418-Male,
pubmed-meshheading:19670418-Mice,
pubmed-meshheading:19670418-Mice, Inbred BALB C,
pubmed-meshheading:19670418-Middle Aged,
pubmed-meshheading:19670418-Prognosis,
pubmed-meshheading:19670418-RNA, Messenger,
pubmed-meshheading:19670418-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19670418-Sensitivity and Specificity,
pubmed-meshheading:19670418-Stomach Neoplasms,
pubmed-meshheading:19670418-Survival Rate,
pubmed-meshheading:19670418-Tumor Cells, Cultured,
pubmed-meshheading:19670418-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients.
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pubmed:affiliation |
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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