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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-8-11
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pubmed:abstractText |
Long QT syndrome (LQTS) is characterized by corrected QT interval prolongation leading to torsades de pointes and sudden cardiac death. LQTS type 2 (LQTS2) is caused by mutations in the KCNH2 gene, leading to a reduction of the rapidly activating delayed rectifier K+ current and loss of human ether-à-go-go-related gene (hERG) channel function by different mechanisms. Triggers for life-threatening arrhythmias in LQTS2 are often auditory stimuli.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-10508236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-10690299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-11104743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-11136691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-11334834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-11790932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-12948624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-1336062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-14998624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-15159030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-16554806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-17353374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-17888503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-6100303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-7604285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-8700910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-9012748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-9234196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-9351462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-9600240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19668779-9663800
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1916-7075
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
455-62
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19668779-Adult,
pubmed-meshheading:19668779-Aged,
pubmed-meshheading:19668779-Electrocardiography,
pubmed-meshheading:19668779-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:19668779-Female,
pubmed-meshheading:19668779-Humans,
pubmed-meshheading:19668779-Long QT Syndrome,
pubmed-meshheading:19668779-Male,
pubmed-meshheading:19668779-Middle Aged,
pubmed-meshheading:19668779-Mutation,
pubmed-meshheading:19668779-Seizures
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pubmed:year |
2009
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pubmed:articleTitle |
Characterization of novel KCNH2 mutations in type 2 long QT syndrome manifesting as seizures.
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pubmed:affiliation |
Cardiology Department, Univesiry Hospital of Basel, Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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