19667267

Source:http://linkedlifedata.com/resource/pubmed/id/19667267

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0600688, umls-concept:C0680730, umls-concept:C0868995, umls-concept:C1148554
pubmed:issue	26
pubmed:dateCreated	2009-9-9
pubmed:abstractText	To identify genetic markers in the pharmacokinetic and pharmacodynamic pathways of sunitinib that predispose for development of toxicities: thrombocytopenia, leukopenia, mucosal inflammation, hand-foot syndrome, and any toxicity according to National Cancer Institute Common Toxicity Criteria higher than grade 2.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19667267
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8309333
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles, http://linkedlifedata.com/resource/pubmed/chemical/sunitinib
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1527-7755
pubmed:author	pubmed-author:Baak-PabloRenée FRF, pubmed-author:BovenEpieE, pubmed-author:EechouteKarelK, pubmed-author:GelderblomHansH, pubmed-author:GuchelaarHenk-JanHJ, pubmed-author:HaanenJohn BJB, pubmed-author:MathijssenRon H JRH, pubmed-author:ReynersAn K LAK, pubmed-author:WesselsJudith A MJA, pubmed-author:van ErpNielka PNP, pubmed-author:van der StraatenTaharT, pubmed-author:van der VeldtAstrid AAA
pubmed:issnType	Electronic
pubmed:day	10
pubmed:volume	27
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4406-12
pubmed:dateRevised	2010-6-2
pubmed:meshHeading	pubmed-meshheading:19667267-Adult, pubmed-meshheading:19667267-Aged, pubmed-meshheading:19667267-Aged, 80 and over, pubmed-meshheading:19667267-Antineoplastic Agents, pubmed-meshheading:19667267-Cytochrome P-450 CYP1A1, pubmed-meshheading:19667267-Drug Toxicity, pubmed-meshheading:19667267-Female, pubmed-meshheading:19667267-Genetic Predisposition to Disease, pubmed-meshheading:19667267-Haplotypes, pubmed-meshheading:19667267-Humans, pubmed-meshheading:19667267-Indoles, pubmed-meshheading:19667267-Leukopenia, pubmed-meshheading:19667267-Male, pubmed-meshheading:19667267-Middle Aged, pubmed-meshheading:19667267-Mucositis, pubmed-meshheading:19667267-Pharmacogenetics, pubmed-meshheading:19667267-Polymorphism, Single Nucleotide, pubmed-meshheading:19667267-Pyrroles, pubmed-meshheading:19667267-Risk Factors, pubmed-meshheading:19667267-Young Adult
pubmed:year	2009
pubmed:articleTitle	Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
pubmed:affiliation	Leiden University Medical Center, Department of Clinical Pharmacy & Toxicology, Leiden, the Netherlands.
pubmed:publicationType	Journal Article, Multicenter Study