|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007272,
umls-concept:C0008976,
umls-concept:C0087111,
umls-concept:C0242618,
umls-concept:C0449416,
umls-concept:C1280412,
umls-concept:C1280500,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1553879,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2827666
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|
pubmed:issue |
4
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|
pubmed:dateCreated |
2009-8-11
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|
pubmed:abstractText |
Studies measuring progression of carotid artery intima-media thickness (cIMT) have been used to estimate the effect of lipid-modifying therapies cardiovascular event risk. The likelihood that future cIMT clinical trials will detect a true treatment effect is estimated by leveraging results from prior studies. The present analyses assess the impact of between- and within-study variability based on currently published data from prior clinical studies on the likelihood that ongoing or future cIMT trials will detect the true treatment effect of lipid-modifying therapies.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1740-7753
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
6
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-19
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19667027-Bayes Theorem,
pubmed-meshheading:19667027-Carotid Arteries,
pubmed-meshheading:19667027-Carotid Artery Diseases,
pubmed-meshheading:19667027-Disease Progression,
pubmed-meshheading:19667027-Humans,
pubmed-meshheading:19667027-Hypolipidemic Agents,
pubmed-meshheading:19667027-Models, Statistical,
pubmed-meshheading:19667027-Monte Carlo Method,
pubmed-meshheading:19667027-Randomized Controlled Trials as Topic,
pubmed-meshheading:19667027-Research,
pubmed-meshheading:19667027-Research Design,
pubmed-meshheading:19667027-Risk Factors,
pubmed-meshheading:19667027-Sample Size,
pubmed-meshheading:19667027-Tunica Intima,
pubmed-meshheading:19667027-Tunica Media
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Effects of sources of variability on sample sizes required for RCTs, applied to trials of lipid-altering therapies on carotid artery intima-media thickness.
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pubmed:affiliation |
Merck Research Laboratories, Rahway, NJ, USA. goulda@merck.com
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pubmed:publicationType |
Journal Article
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