Linked Life Data

1966651

Source:http://linkedlifedata.com/resource/pubmed/id/1966651

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-11-21
pubmed:abstractText
Neutrophil infiltration in the ischemic porcine hearts was analyzed by spectrophotometrical assay of the neutrophil specific enzyme-myeloperoxidase (MPO). The results showed that neutrophil infiltration in the ischemic myocardium was increased with time. An increase of MPO activity per 1 g tissue from 1.3 +/- 0.8 to 4 +/- 3 IU was observed as early as 10 min after occlusion of the coronary artery. Three h after occlusion MPO activity increased to 8.4 +/- 1.3 IU, 7 times greater than that of normal tissue. One-h occlusion followed by 2-h reperfusion caused even higher neutrophil accumulation. MPO activity increased to 14 +/- 3 IU, 11 times greater than normal tissue. Pretreatment with verapamil to reperfusion hearts decreased MPO activity to 4.7 +/- 0.7 IU. In addition, verapamil completely eliminated the first episode of arrhythmia 5-10 min after occlusion. Our studies demonstrate that neutrophils can rapidly accumulate into the ischemic myocardium and suggest that the protective action of verapamil may in part due to its inhibition of neutrophil infiltration in the ischemic myocardium.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Neutrophil infiltration in ischemic porcine myocardium and protective effect of verapamil].
pubmed:affiliation
Research Section of Pharmacology, Hu-nan Medical University, Changsha, China.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't