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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-9-23
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pubmed:abstractText |
We have demonstrated that valproic acid (VPA), a histone deacetylase inhibitor (HDACI), can improve animal survival after hemorrhagic shock, and protect neurons from hypoxia-induced apoptosis. This study investigated whether VPA treatment works through the c-Jun N-terminal kinase (JNK)/Caspase-3 survival pathways.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19665733-Animals,
pubmed-meshheading:19665733-Apoptosis,
pubmed-meshheading:19665733-Caspase 3,
pubmed-meshheading:19665733-Cell Survival,
pubmed-meshheading:19665733-Disease Models, Animal,
pubmed-meshheading:19665733-Enzyme Inhibitors,
pubmed-meshheading:19665733-Histone Deacetylase Inhibitors,
pubmed-meshheading:19665733-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:19665733-Liver,
pubmed-meshheading:19665733-Rats,
pubmed-meshheading:19665733-Shock, Hemorrhagic,
pubmed-meshheading:19665733-Signal Transduction,
pubmed-meshheading:19665733-Valproic Acid
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pubmed:year |
2009
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pubmed:articleTitle |
Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock.
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pubmed:affiliation |
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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