Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-10-21
|
| pubmed:abstractText |
We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron. Experimental conditions selected for study were acute (60-min) and chronic hydrochlorothiazide (HCTZ), acute acetazolamide, acute and chronic furosemide, and 14 days of varied intake of dietary sodium. The density of the binding of 3H-metolazone was increased 47% by acute HCTZ (P less than 0.001) and 39% (P less than 0.001) by acute furosemide. In contrast, acute acetazolamide produced no change in binding despite eliciting a dramatic diuresis. Chronic HCTZ (5 days) and chronic furosemide (7 days) increased binding of 3H-metolazone by 46% (P less than 0.001) and by 101% (P less than 0.001), respectively. Variation of dietary sodium intake over a range that allowed normal growth of the animal and that produced urinary excretion of Na varying from 0.28 to 2.62 mEq/100 g/day failed to alter the density of binding of 3H-metolazone. These studies are the first indication that the density of the thiazide receptor is regulated by a variety of both acute and chronic conditions that have previously been associated with changes in transport, ultrastructure or Na-K-ATPase activity in the distal nephron.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetazolamide,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Diuretics,
http://linkedlifedata.com/resource/pubmed/chemical/Furosemide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrochlorothiazide,
http://linkedlifedata.com/resource/pubmed/chemical/Metolazone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Slc12a3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/thiazide receptor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1046-6673
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
91-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1966553-Acetazolamide,
pubmed-meshheading:1966553-Animals,
pubmed-meshheading:1966553-Carrier Proteins,
pubmed-meshheading:1966553-Diuretics,
pubmed-meshheading:1966553-Furosemide,
pubmed-meshheading:1966553-Hydrochlorothiazide,
pubmed-meshheading:1966553-Kidney,
pubmed-meshheading:1966553-Male,
pubmed-meshheading:1966553-Metolazone,
pubmed-meshheading:1966553-Rats,
pubmed-meshheading:1966553-Rats, Inbred Strains,
pubmed-meshheading:1966553-Receptors, Drug,
pubmed-meshheading:1966553-Sodium, Dietary,
pubmed-meshheading:1966553-Sodium Chloride Symporters,
pubmed-meshheading:1966553-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:1966553-Symporters
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Effects of diuretic treatment and of dietary sodium on renal binding of 3H-metolazone.
|
| pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla 92093-0623.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|