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rdf:type |
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lifeskim:mentions |
umls-concept:C0003501,
umls-concept:C0017262,
umls-concept:C0023602,
umls-concept:C0035820,
umls-concept:C0069676,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0450131,
umls-concept:C0600388,
umls-concept:C1416962,
umls-concept:C1419771,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2009-9-22
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pubmed:abstractText |
Bone morphogenic protein 2 is found in calcified areas of stenotic aortic valves, and prolonged stimulation of aortic valve interstitial cells with bone morphogenic protein 2 results in increased expression of alkaline phosphatase, indicating a mechanistic role for bone morphogenic protein 2 in aortic valve calcification. The purposes of this study were to assess the effect of bone morphogenic protein 2 on the expression of the osteogenic factors Runx2 and osteopontin in human aortic valve interstitial cells and to determine the signaling mechanisms that mediate the expression of these early osteogenic factors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1008-15
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19664780-Aged,
pubmed-meshheading:19664780-Aortic Valve,
pubmed-meshheading:19664780-Aortic Valve Stenosis,
pubmed-meshheading:19664780-Bone Morphogenetic Protein 2,
pubmed-meshheading:19664780-Calcinosis,
pubmed-meshheading:19664780-Cells, Cultured,
pubmed-meshheading:19664780-Core Binding Factor Alpha 1 Subunit,
pubmed-meshheading:19664780-Female,
pubmed-meshheading:19664780-Humans,
pubmed-meshheading:19664780-Immunohistochemistry,
pubmed-meshheading:19664780-Male,
pubmed-meshheading:19664780-Middle Aged,
pubmed-meshheading:19664780-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19664780-Osteopontin,
pubmed-meshheading:19664780-Signal Transduction,
pubmed-meshheading:19664780-Smad1 Protein,
pubmed-meshheading:19664780-Up-Regulation,
pubmed-meshheading:19664780-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Denver, Aurora, Colo., USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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