Linked Life Data

1966411

Source:http://linkedlifedata.com/resource/pubmed/id/1966411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-10-1
pubmed:abstractText
The results in this study suggest a unique possible association between inhibition of JHMV replication and the induction of R1 proteins in differentiating oligodendrocytes, involving inhibition of a PPPase found in the endosome fractions of cells. Free R1 protein appears to prevent the dephosphorylation of purified JHMV-NC substrate thereby possibly blocking the normal sequence of events necessary for NC release of viral genomes. Inhibition of host-cell endosome PPPase's may have relevance to controlling JHMV infection since CV particles adsorbing to cell surface receptors are believed to penetrate via clathrin coated pits into endosomes. Thus, the early stages of CV infection, including dephosphorylation of NC protein within endosomes, provide a possible site for controlling the initial stages of viral infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
276
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
In vivo and in vitro models of demyelinating disease. Possible relationship between induction of regulatory subunit from cAMP dependent protein kinases and inhibition of JHMV replication in cultured oligodendrocytes.
pubmed:affiliation
Dept. of Microbiology and Immunology, Univ. of Western Ontario, London, Canada.
pubmed:publicationType
Journal Article