| pubmed-article:19661680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0600139 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C2936592 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0079941 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C2677316 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19661680 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19661680 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19661680 | pubmed:dateCreated | 2009-8-24 | lld:pubmed |
| pubmed-article:19661680 | pubmed:abstractText | 8S-Lipoxygenase (8S-LOX) is known as a mouse homolog of human 15S-LOX-2. 15S-LOX-2 was down-regulated in malignant transformation of prostate epithelial cells, and its overexpression caused cell cycle arrest. To determine whether 8S-LOX would have a growth inhibitory effect on prostate carcinoma, we obtained human prostate carcinoma PC-3 cells expressing 8S-LOX or 15S-LOX-2. The growth rate of cells measured by colorimetric assay was reduced by expression of 8S-LOX and 15S-LOX-2. The addition to enzyme-expressing cells of arachidonic acid enhanced the growth suppressive effect, whereas the expression of catalytically inactive mutants did not affect cell growth, suggesting that the effect was product-dependent. DNA microarray and quantitative reverse transcription-PCR analyses revealed that the c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 (CRD-BP/IMP-1), known as an oncofetal protein, was down-regulated in 8S-LOX- and 15S-LOX-2-expressing PC-3 cells. Targeted knockdown of CRD-BP/IMP-1 resulted in inhibition of the DNA synthesis rate of PC-3 cells as measured by bromodeoxyuridine incorporation. We propose that expression of 8S-LOX and 15S-LOX-2 suppresses CRD-BP/IMP-1 expression, resulting in inhibition of human prostate carcinoma PC-3 cell proliferation. | lld:pubmed |
| pubmed-article:19661680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19661680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661680 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19661680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19661680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19661680 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19661680 | pubmed:issn | 1347-6947 | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:YamashitaHiro... | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:TanakaJunkoJ | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:YoshimotoTani... | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:MiwaYoshihiro... | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:KimotoMasumiM | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:TsujiHideakiH | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:JisakaMitsuoM | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:TakahashiYosh... | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:KawakamiYukiY | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:Suzuki-Yamamo... | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:KubotaNoriyuk... | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:EkuniNatsukiN | lld:pubmed |
| pubmed-article:19661680 | pubmed:author | pubmed-author:FujimuraHirof... | lld:pubmed |
| pubmed-article:19661680 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19661680 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:19661680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19661680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19661680 | pubmed:pagination | 1811-7 | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:meshHeading | pubmed-meshheading:19661680... | lld:pubmed |
| pubmed-article:19661680 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19661680 | pubmed:articleTitle | Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells. | lld:pubmed |
| pubmed-article:19661680 | pubmed:affiliation | Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan. | lld:pubmed |
| pubmed-article:19661680 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19661680 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:247 | entrezgene:pubmed | pubmed-article:19661680 | lld:entrezgene |
| entrez-gene:10642 | entrezgene:pubmed | pubmed-article:19661680 | lld:entrezgene |
| entrez-gene:11688 | entrezgene:pubmed | pubmed-article:19661680 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19661680 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19661680 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19661680 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19661680 | lld:pubmed |
