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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-8-28
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pubmed:abstractText |
T-box transcription factors play critical roles in the coordinated formation of the working chambers and the atrioventricular canal (AVC). Tbx2 patterns embryonic myocardial cells to form the AVC and suppresses their differentiation into chamber myocardium. Tbx20-deficient embryos, which fail to form chambers, ectopically express Tbx2 throughout the entire heart tube, providing a potential mechanism for the function of Tbx20 in chamber differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad5 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tbx20 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
442-52
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pubmed:meshHeading |
pubmed-meshheading:19661464-Animals,
pubmed-meshheading:19661464-Base Sequence,
pubmed-meshheading:19661464-Binding Sites,
pubmed-meshheading:19661464-Bone Morphogenetic Proteins,
pubmed-meshheading:19661464-Cell Differentiation,
pubmed-meshheading:19661464-Endocardial Cushions,
pubmed-meshheading:19661464-Gene Expression Regulation, Developmental,
pubmed-meshheading:19661464-Gestational Age,
pubmed-meshheading:19661464-HeLa Cells,
pubmed-meshheading:19661464-Heart Atria,
pubmed-meshheading:19661464-Heart Ventricles,
pubmed-meshheading:19661464-Humans,
pubmed-meshheading:19661464-Mice,
pubmed-meshheading:19661464-Mice, Knockout,
pubmed-meshheading:19661464-Molecular Sequence Data,
pubmed-meshheading:19661464-Mutation,
pubmed-meshheading:19661464-Myocytes, Cardiac,
pubmed-meshheading:19661464-Promoter Regions, Genetic,
pubmed-meshheading:19661464-Signal Transduction,
pubmed-meshheading:19661464-Smad Proteins,
pubmed-meshheading:19661464-Smad1 Protein,
pubmed-meshheading:19661464-Smad4 Protein,
pubmed-meshheading:19661464-Smad5 Protein,
pubmed-meshheading:19661464-T-Box Domain Proteins,
pubmed-meshheading:19661464-Transcriptional Activation,
pubmed-meshheading:19661464-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.
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pubmed:affiliation |
Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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