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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-11-9
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pubmed:abstractText |
Hyperoxia-induced acute lung injury has been used for many years as a model of oxidative stress mimicking clinical acute lung injury and the acute respiratory distress syndrome. Excess quantities of reactive oxygen species (ROS) are responsible for oxidative stress-induced lung injury. ROS are produced by mitochondrial chain transport, but also by NADPH oxidase (NOX) family members. Although NOX1 and NOX2 are expressed in the lungs, their precise function has not been determined until now.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1535-4970
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
972-81
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pubmed:dateRevised |
2010-11-22
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pubmed:meshHeading |
pubmed-meshheading:19661248-Animals,
pubmed-meshheading:19661248-Anoxia,
pubmed-meshheading:19661248-Cell Death,
pubmed-meshheading:19661248-Endothelium,
pubmed-meshheading:19661248-Epithelial Cells,
pubmed-meshheading:19661248-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:19661248-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:19661248-Lung,
pubmed-meshheading:19661248-Lung Injury,
pubmed-meshheading:19661248-Mice,
pubmed-meshheading:19661248-Mice, Inbred C57BL,
pubmed-meshheading:19661248-NADPH Oxidase,
pubmed-meshheading:19661248-Phosphorylation,
pubmed-meshheading:19661248-Reactive Oxygen Species
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pubmed:year |
2009
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pubmed:articleTitle |
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.
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pubmed:affiliation |
Department of Pediatrics and Department of Pathology and Immunology, Centre Médical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland. Stephanie.Carnesecchi@unige.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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