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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-8-25
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pubmed:abstractText |
Concomitant chemotherapy and radiotherapy (chemoradiation; CRT) is the standard treatment for locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). CRT improves local control and overall survival (OS) when compared to radiotherapy (RT) alone. Induction chemotherapy (IC) reduces the risk of distant metastases (DM) and improves OS by 5% with the use of cisplatin/infusional 5 fluorouracil (PF) in meta-analysis. Adding a taxane to PF in the IC regimen confers a better outcome. Sequential treatment (ST) of IC followed by CRT is therefore under active investigation in multiple phase III trials.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-10768432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-11189100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-12182996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-12506176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-12738315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-14529773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-15547184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-15958469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-16275937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-16451730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-17673364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-17960012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-17960013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-18544437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-8158680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19660134-9424004
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273
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pubmed:meshHeading |
pubmed-meshheading:19660134-Adult,
pubmed-meshheading:19660134-Aged,
pubmed-meshheading:19660134-Antimetabolites, Antineoplastic,
pubmed-meshheading:19660134-Carcinoma, Squamous Cell,
pubmed-meshheading:19660134-Cisplatin,
pubmed-meshheading:19660134-Cohort Studies,
pubmed-meshheading:19660134-Combined Modality Therapy,
pubmed-meshheading:19660134-Deoxycytidine,
pubmed-meshheading:19660134-Female,
pubmed-meshheading:19660134-Head and Neck Neoplasms,
pubmed-meshheading:19660134-Humans,
pubmed-meshheading:19660134-Male,
pubmed-meshheading:19660134-Middle Aged,
pubmed-meshheading:19660134-Neoplasm Metastasis,
pubmed-meshheading:19660134-Proportional Hazards Models,
pubmed-meshheading:19660134-Radiation-Sensitizing Agents,
pubmed-meshheading:19660134-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
A non-randomized comparison of gemcitabine-based chemoradiation with or without induction chemotherapy for locally advanced squamous cell carcinoma of the head and neck.
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pubmed:affiliation |
Department of Medical Oncology, Antwerp University Hospital Antwerp, Edegem, Belgium. pol.specenier@pandora.be
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pubmed:publicationType |
Journal Article
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