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pubmed-article:19657750pubmed:abstractTextAtypical chronic myeloid leukaemia (aCML) belongs to the myeloproliferative/myelodysplastic category of haematological disease. Main characteristics are marked dysgranulopoiesis, bone marrow dysfunction and the failure to demonstrate the presence of the Philadelphia chromosome or BCR/ABL fusion gene normally associated with CML t(9;22)(q34;q11). It carries a poor prognosis with limited therapeutic options available. Most cases of aCML have one or more karyotypic abnormalities. We highlight a clinical presentation of aCML associated with an acquired reciprocal whole-arm translocation (WAT), t(X;12)(p10;p10), which to our knowledge has not yet been described. We also discuss how such a translocation might lead to tumorigenesis.lld:pubmed
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pubmed-article:19657750pubmed:articleTitleThe finding of a reciprocal whole-arm translocation t(X;12)(p10;p10) in association with atypical chronic myeloid leukaemia.lld:pubmed
pubmed-article:19657750pubmed:affiliationDepartment of Haematology, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, BT9-7AB, UK. patrickelder@doctors.org.uklld:pubmed
pubmed-article:19657750pubmed:publicationTypeJournal Articlelld:pubmed
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