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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0040715,
umls-concept:C0243095,
umls-concept:C0349640,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1425194,
umls-concept:C1522702,
umls-concept:C1548702,
umls-concept:C1882911
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pubmed:issue |
3
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|
pubmed:dateCreated |
2010-8-20
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|
pubmed:abstractText |
Atypical chronic myeloid leukaemia (aCML) belongs to the myeloproliferative/myelodysplastic category of haematological disease. Main characteristics are marked dysgranulopoiesis, bone marrow dysfunction and the failure to demonstrate the presence of the Philadelphia chromosome or BCR/ABL fusion gene normally associated with CML t(9;22)(q34;q11). It carries a poor prognosis with limited therapeutic options available. Most cases of aCML have one or more karyotypic abnormalities. We highlight a clinical presentation of aCML associated with an acquired reciprocal whole-arm translocation (WAT), t(X;12)(p10;p10), which to our knowledge has not yet been described. We also discuss how such a translocation might lead to tumorigenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1559-131X
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
760-2
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pubmed:meshHeading |
pubmed-meshheading:19657750-Aged,
pubmed-meshheading:19657750-Cell Transformation, Neoplastic,
pubmed-meshheading:19657750-Chromosomes, Human, Pair 12,
pubmed-meshheading:19657750-Chromosomes, Human, X,
pubmed-meshheading:19657750-Clone Cells,
pubmed-meshheading:19657750-Combined Modality Therapy,
pubmed-meshheading:19657750-Cranial Irradiation,
pubmed-meshheading:19657750-Female,
pubmed-meshheading:19657750-Humans,
pubmed-meshheading:19657750-Hypophysectomy,
pubmed-meshheading:19657750-Incidental Findings,
pubmed-meshheading:19657750-Karyotyping,
pubmed-meshheading:19657750-Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative,
pubmed-meshheading:19657750-Neoplasms, Second Primary,
pubmed-meshheading:19657750-Neoplastic Stem Cells,
pubmed-meshheading:19657750-Octreotide,
pubmed-meshheading:19657750-Pituitary Neoplasms,
pubmed-meshheading:19657750-Radiotherapy, Adjuvant,
pubmed-meshheading:19657750-Translocation, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
The finding of a reciprocal whole-arm translocation t(X;12)(p10;p10) in association with atypical chronic myeloid leukaemia.
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pubmed:affiliation |
Department of Haematology, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, BT9-7AB, UK. patrickelder@doctors.org.uk
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pubmed:publicationType |
Journal Article,
Case Reports
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