Source:http://linkedlifedata.com/resource/pubmed/id/19657731
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-3-19
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| pubmed:abstractText |
The association of polymorphisms of tumor suppressor gene TP53 with breast cancer has widely been reported; however, the results are inconsistent. Here, we selected three commonly studied TP53 polymorphisms: codon 72 Arg > Pro, IVS3 16 bp Del/Ins, and IVS6 + 62A > G to explore their association with breast cancer risk by meta-analysis of published case-control studies. The results showed that codon 72 was not associated with breast cancer risk among 37 combined case-control studies (23,567 cases and 25,995 controls). However, a significant association with decreased risk of breast cancer was found in the Mediterranean studies (PP + PR vs. RR: OR = 0.32, 95% CI = 0.24-0.44, P < 0.001; PP vs. RR: OR = 0.35, 95% CI = 0.21-0.60, P < 0.001). IVS3 16 bp Del/Ins was significantly associated with an increased risk of developing breast cancer in a pooled 8 study dataset (2,470 cases and 2,825 controls; Ins/Ins + Del/Ins vs. Del/Del: OR = 1.15, 95% CI = 1.01-1.30, P = 0.04; Ins/Ins vs. Del/Del: OR = 1.75, 95% CI = 1.20-2.37, P = 0.003). No significant association was observed between IVS6 + 62A > G and breast cancer risk in a total of 10 studies (8,537 cases and 9,586 controls). These results suggest that IVS3 16 bp Del/Ins is likely an important genetic marker contributing to susceptibility of breast cancer, and codon 72 has a potential role in association with breast cancer risk within certain populations or regions.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1573-7217
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
120
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
705-14
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| pubmed:dateRevised |
2011-2-14
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| pubmed:meshHeading |
pubmed-meshheading:19657731-Adult,
pubmed-meshheading:19657731-Aged,
pubmed-meshheading:19657731-Aged, 80 and over,
pubmed-meshheading:19657731-Asia,
pubmed-meshheading:19657731-Breast Neoplasms,
pubmed-meshheading:19657731-Case-Control Studies,
pubmed-meshheading:19657731-Codon,
pubmed-meshheading:19657731-Europe,
pubmed-meshheading:19657731-Female,
pubmed-meshheading:19657731-Genes, p53,
pubmed-meshheading:19657731-Genetic Predisposition to Disease,
pubmed-meshheading:19657731-Humans,
pubmed-meshheading:19657731-Mediterranean Region,
pubmed-meshheading:19657731-Middle Aged,
pubmed-meshheading:19657731-Mutagenesis, Insertional,
pubmed-meshheading:19657731-Polymorphism, Genetic,
pubmed-meshheading:19657731-Polymorphism, Single Nucleotide,
pubmed-meshheading:19657731-Risk,
pubmed-meshheading:19657731-Sequence Deletion,
pubmed-meshheading:19657731-United States,
pubmed-meshheading:19657731-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Three common TP53 polymorphisms in susceptibility to breast cancer, evidence from meta-analysis.
|
| pubmed:affiliation |
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
|