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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2009-9-24
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pubmed:abstractText |
The administration of vectors designed to elicited cell-mediated immune responses may have other consequences that are clinically significant. To explore this possibility, we evaluated T-cell activation during the first 2 months after recombinant adenovirus serotype 5 (rAd5) prime or boost immunizations in rhesus monkeys. We also evaluated the kinetics of T-lymphocyte activation in both the systemic and the mucosal compartments after rAd5 administration in monkeys with preexisting immunity to Ad5. The rAd5 immunization induced lower-frequency Gag epitope-specific CD8+ T cells in the colonic mucosa than in the peripheral blood. There was evidence of an expansion of the simian immunodeficiency virus Gag-specific CD8+ T-cell responses, but not the Ad5 hexon-specific T-cell responses, following a homologous rAd5 boost. A striking but transient T-lymphocyte activation in both the systemic and the mucosal compartments of rhesus monkeys was observed after rAd5 immunization. These findings indicate that the administration of a vaccine vector such as Ad5 can induce a global activation of T cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-14605137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-14746526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-15220422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-16467198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-16763152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-16943292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-18468671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-18579590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-19012954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-19012957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-19297477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-19339347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-19620961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-9565630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19656883-9933172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10596-604
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19656883-Adenoviridae,
pubmed-meshheading:19656883-Animals,
pubmed-meshheading:19656883-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19656883-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19656883-Genetic Vectors,
pubmed-meshheading:19656883-Immunization,
pubmed-meshheading:19656883-Immunization, Secondary,
pubmed-meshheading:19656883-Lymphocyte Activation,
pubmed-meshheading:19656883-Macaca mulatta,
pubmed-meshheading:19656883-T-Lymphocytes,
pubmed-meshheading:19656883-Vaccines, Synthetic,
pubmed-meshheading:19656883-Viral Vaccines
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pubmed:year |
2009
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pubmed:articleTitle |
Systemic and mucosal T-lymphocyte activation induced by recombinant adenovirus vaccines in rhesus monkeys.
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pubmed:affiliation |
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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