Source:http://linkedlifedata.com/resource/pubmed/id/19656178
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| lifeskim:mentions |
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| pubmed:issue |
3
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| pubmed:dateCreated |
2009-8-18
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| pubmed:abstractText |
The composition of N-methyl-D-aspartate (NMDA) receptor subunits influences the degree of synaptic plasticity expressed during development and into adulthood. Here, we show that theta-burst stimulation of the medial geniculate nucleus reliably induced NMDA receptor-dependent long-term potentiation (LTP) of field postsynaptic potentials recorded in the primary auditory cortex (A1) of urethane-anesthetized rats. Furthermore, substantially greater levels of LTP were elicited in juvenile animals (30-37 days old; approximately 55% maximal potentiation) than in adult animals (approximately 30% potentiation). Masking patterned sound via continuous white noise exposure during early postnatal life (from postnatal day 5 to postnatal day 50-60) resulted in enhanced, juvenile-like levels of LTP (approximately 70% maximal potentiation) relative to age-matched controls reared in unaltered acoustic environments (approximately 30%). Rats reared in white noise and then placed in unaltered acoustic environments for 40-50 days showed levels of LTP comparable to those of adult controls, indicating that white noise rearing results in a form of developmental arrest that can be overcome by subsequent patterned sound exposure. We explored the mechanisms mediating white noise-induced plasticity enhancements by local NR2B subunit antagonist application in A1. NR2B subunit antagonists (Ro 25-6981 or ifenprodil) completely reversed white noise-induced LTP enhancement at concentrations that did not affect LTP in adult or age-matched controls. We conclude that white noise exposure during early postnatal life results in the maintenance of juvenile-like, higher levels of plasticity in A1, an effect that appears to be critically dependent on NR2B subunit activation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1460-9568
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
376-84
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| pubmed:meshHeading |
pubmed-meshheading:19656178-Animals,
pubmed-meshheading:19656178-Animals, Newborn,
pubmed-meshheading:19656178-Auditory Cortex,
pubmed-meshheading:19656178-Long-Term Potentiation,
pubmed-meshheading:19656178-Male,
pubmed-meshheading:19656178-Noise,
pubmed-meshheading:19656178-Rats,
pubmed-meshheading:19656178-Rats, Long-Evans,
pubmed-meshheading:19656178-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:19656178-Sensory Deprivation,
pubmed-meshheading:19656178-Synaptic Potentials
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| pubmed:year |
2009
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| pubmed:articleTitle |
NR2B subunit-dependent long-term potentiation enhancement in the rat cortical auditory system in vivo following masking of patterned auditory input by white noise exposure during early postnatal life.
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| pubmed:affiliation |
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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